Adrenaline ELISA Kits

靶标信息

Adrenaline, also known as epinephrine, plays a critical role in the body's acute stress response and is synthesized from noradrenaline in catecholaminergic neurons. The biosynthesis involves four key enzymes. The process begins with tyrosine conversion into L-DOPA by tyrosine hydroxylase, followed by L-DOPA conversion to dopamine by aromatic L-amino acid decarboxylase. Dopamine is subsequently converted into noradrenaline by dopamine-beta-hydroxylase. The final step is the conversion of noradrenaline into adrenaline through phenylethanolamine N-methyltransferase (PNMT), which utilizes the cofactor S-adenosyl-L-methionine to catalyze the methylation. Adrenaline exerts its physiological effects by binding to adrenergic receptors, which belong to the G protein-coupled receptor (GPCR) superfamily. These receptors are integral to mediating the cardiovascular effects of catecholamines, contributing to increased heart rate, blood pressure, and energy mobilization. The presence of adrenaline in the central nervous system (CNS) accounts for a small portion of catecholamines, yet its function is significant in synaptic transmission and neuromodulation, as it facilitates synchronized acetylcholine release, thus impacting neuronal communication and muscle function.