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Abstract
Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins.
Authors Hurne Alanna M; Chai Christina L L; Moerman Katherine; Waring Paul;
JournalJ Biol Chem
PubMed ID12063251
'Gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins, induces both apoptotic and necrotic cell death in a concentration-dependent manner. Whereas the specific trigger for apoptotic death caused by these toxins is unclear, the reactive disulfide bond in the ETP toxins is required for biological activity. Thus it is ... More
Antagonism between Ena/VASP Proteins and Actin Filament Capping Regulates Fibroblast Motility.
Authors Bear James E; Svitkina Tatyana M; Krause Matthias; Schafer Dorothy A; Loureiro Joseph J; Strasser Geraldine A; Maly Ivan V; Chaga Oleg Y; Cooper John A; Borisy Gary G; Gertler Frank B;
JournalCell
PubMed ID12086607
'Cell motility requires lamellipodial protrusion, a process driven by actin polymerization. Ena/VASP proteins accumulate in protruding lamellipodia and promote the rapid actin-driven motility of the pathogen Listeria. In contrast, Ena/VASP negatively regulate cell translocation. To resolve this paradox, we analyzed the function of Ena/VASP during lamellipodial protrusion. Ena/VASP-deficient lamellipodia protruded ... More
A serum- and antioxidant-free primary culture model of mouse cortical neurons for pharmacological screen and studies of neurotrophic and neuroprotective agents.
AuthorsYu X, An L,
JournalCell Mol Neurobiol
PubMed ID12363202
'1. Morphologically developmental properties of fetal mouse cortical neurons in the chemically defined serum- and antioxidant-free culture condition were observed. Also, cellular composition in cultures was identified by immunostaining with anti-NSE and anti-GFAP. 2. Various cell densities ranging from 1 x 10(3) to 1 x 10(6) cells/cm2 were prepared to ... More
Acute hippocampal slice preparation and hippocampal slice cultures.
AuthorsLein PJ, Barnhart CD, Pessah IN
JournalMethods Mol Biol
PubMed ID21815062
'A major advantage of hippocampal slice preparations is that the cytoarchitecture and synaptic circuits of the hippocampus are largely retained. In neurotoxicology research, organotypic hippocampal slices have mostly been used as acute ex vivo preparations for investigating the effects of neurotoxic chemicals on synaptic function. More recently, hippocampal slice cultures, ... More
The Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells.
AuthorsEdelson JR, Brautigan DL
JournalToxins (Basel)
PubMed ID22069692
'Cyclin D1 is a key regulator of the cell cycle that is over expressed in more than half of breast cancer patients. The levels of cyclin D1 are controlled primarily through post-translational mechanisms and phosphorylation of cyclin D1 at T286 induces its proteasomal degradation. To date, no studies have explored ... More
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.
The peroxisome proliferator-activated receptor (PPAR) alpha agonist WY 14,643 increased the secretion of apolipoprotein (apo) B-100, but not that of apoB-48, and decreased triglyceride biosynthesis and secretion from primary rat hepatocytes. These effects resulted in decreased secretion of apoB-100-very low density lipoprotein (VLDL) and an increased secretion of apoB-100 on ... More
Alternative mRNA splicing and differential promoter utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. Structure and evolution of Apobec1 and related nucleoside/nucleotide deaminases.
Authors Nakamuta M; Oka K; Krushkal J; Kobayashi K; Yamamoto M; Li W H; Chan L;
JournalJ Biol Chem
PubMed ID7768898
Apolipoprotein (apo) B mRNA editing consists of a C-->U conversion involving the first base of the codon CAA, encoding Gln 2153, to UAA, a stop codon. Editing occurs in the intestine only in most mammals, and in both the liver and intestine in a few mammalian species including mouse. We ... More
Heterotrimeric G-proteins Activate Cl- Channels through Stimulation of a Cyclooxygenase-dependent Pathway in a Model Liver Cell Line.
Authors Kilic Gordan; Fitz J Gregory;
JournalJ Biol Chem
PubMed ID11812774
Circulating hormones produce rapid changes in the Cl(-) permeability of liver cells through activation of plasma membrane receptors coupled to heterotrimeric G-proteins. The resulting effects on intracellular pH, membrane potential, and Cl(-) content are important contributors to the overall metabolic response. Consequently, the purpose of these studies was to evaluate ... More