'Dasatinib is an oral small molecule inhibitor of Abl and Src family tyrosine kinases (SFK), including p56(Lck) (Lck). Given the central importance of Lck in transmitting signals from the T cell receptor (TCR) signaling complex, and the potent ability of dasatinib to inhibit Lck activity, we hypothesized this agent could ... More
Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection.
AuthorsLarrea E, Riezu-Boj JI, Gil-Guerrero L, Casares N, Aldabe R, Sarobe P, Civeira MP, Heeney JL, Rollier C, Verstrepen B, Wakita T, Borrás-Cuesta F, Lasarte JJ, Prieto J,
JournalJ Virol
PubMed ID17229698
Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral immune tolerance. In chronic hepatitis C, we found upregulation of IDO expression in the liver and an increased serum kynurenine/tryptophan ratio (a reflection of IDO activity). Huh7 cells supporting hepatitis ... More
Activated human CD4+ T cells express transporters for both cysteine and cystine.
AuthorsLevring TB, Hansen AK, Nielsen BL, Kongsbak M, von Essen MR, Woetmann A, Odum N, Bonefeld CM, Geisler C,
JournalSci Rep
PubMed ID22355778
Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine ... More
Loss of Siglec expression on T lymphocytes during human evolution.
AuthorsNguyen DH, Hurtado-Ziola N, Gagneux P, Varki A
JournalProc Natl Acad Sci U S A
PubMed ID16682635
We report here that human T cells give much stronger proliferative responses to specific activation via the T cell receptor (TCR) than those from chimpanzees, our closest evolutionary relatives. Nonspecific activation using phytohemagglutinin was robust in chimpanzee T cells, indicating that the much lower response to TCR simulation is not ... More