Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation.
AuthorsValcourt U, Merle B, Gineyts E, Viguet-Carrin S, Delmas PD, Garnero P,
JournalJ Biol Chem
PubMed ID17142454
Type I collagen, the major organic component of bone matrix, undergoes a series of post-translational modifications that occur with aging, such as the non-enzymatic glycation. This spontaneous reaction leads to the formation of advanced glycation end products (AGEs), which accumulate in bone tissue and affect its structural and mechanical properties. ... More
Collaborative action of NF-kappaB and p38 MAPK is involved in CpG DNA-induced IFN-alpha and chemokine production in human plasmacytoid dendritic cells.
AuthorsOsawa Y, Iho S, Takauji R, Takatsuka H, Yamamoto S, Takahashi T, Horiguchi S, Urasaki Y, Matsuki T, Fujieda S,
JournalJ Immunol
PubMed ID16982926
CpG DNA induces plasmacytoid dendritic cells (pDC) to produce type I IFN and chemokines. However, it has not been fully elucidated how the TLR9 signaling pathway is linked to these gene expressions. We examined the mechanisms involving the TLR9 and type I IFN signaling pathways, in relation to CpG DNA-induced ... More
T regulatory-1 cells induce IgG4 production by B cells: role of IL-10.
AuthorsSatoguina JS, Weyand E, Larbi J, Hoerauf A,
JournalJ Immunol
PubMed ID15814696
The study was aimed to find out whether T cells with a regulatory profile could regulate the secretion of IgG4. Using tetanus Ag we found that PBMC of healthy human donors responded to exogenous IL-10 by down-regulating IgG1 and increasing IgG4 secretion. IgE was not affected. To investigate the direct ... More