Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection.
AuthorsVerschoor A, Brockman MA, Gadjeva M, Knipe DM, Carroll MC,
JournalJ Immunol
PubMed ID14607939
'The complement system, in addition to its role in innate immunity, is an important regulator of the B cell response. Complement exists predominantly in the circulation and although the primary source is hepatic, multiple additional cellular sources have been described that can contribute substantially to the complement pool. To date, ... More
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease.
AuthorsPaust S, Lu L, McCarty N, Cantor H,
JournalProc Natl Acad Sci U S A
PubMed ID15235129
'Although there is considerable evidence that a subpopulation of regulatory CD4(+)CD25+ T cells can suppress the response of autoreactive T cells, the underlying molecular mechanism is not understood. We find that transmission of a suppressive signal by CD4CD25+ regulatory cells requires engagement of the B7 molecule expressed on target T ... More
Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor on naive B cells.
AuthorsLazdina U, Cao T, Steinbergs J, Alheim M, Pumpens P, Peterson DL, Milich DR, Leroux-Roels G, Sällberg M,
JournalJ Virol
PubMed ID11413303
'The nucleocapsid of the hepatitis B virus (HBV) is composed of 180 to 240 copies of the HBV core (HBc) protein. HBc antigen (HBcAg) capsids are extremely immunogenic and can activate naive B cells by cross-linking their surface receptors. The molecular basis for the interaction between HBcAg and naive B ... More
A sexual dimorphism in intrathymic sialylation survey is revealed by the trans-sialidase from Trypanosoma cruzi.
AuthorsMucci J, Mocetti E, Leguizamón MS, Campetella O,
JournalJ Immunol
PubMed ID15814675
Sialylation is emerging as an important issue in developing thymocytes and is considered among the most significant cell surface modifications, although its physiologic relevance is far from being completely understood. It is regulated by the concerted expression of sialyl transferases along thymocyte development. After in vivo administration of trans-sialidase, a ... More
Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors.
AuthorsBrody JD, Goldstein MJ, Czerwinski DK, Levy R,
JournalBlood
PubMed ID18812472
Ex vivo-expanded tumor-infiltrating lymphocytes infused into lymphodepleted recipients has clear antitumor efficacy. More practical sources of such antitumor lymphocytes would broaden the application of this approach. Previously, we described an in situ vaccination combining chemotherapy with intratumoral injection of CpG-enriched oligonucleotides, which induced T-cell immunity against established lymphoma. An ongoing ... More