Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis.
AuthorsRoberts SJ,Ng BY,Filler RB,Lewis J,Glusac EJ,Hayday AC,Tigelaar RE,Girardi M
JournalProceedings of the National Academy of Sciences of the United States of America
PubMed ID17412837
There is a longstanding but poorly understood epidemiologic link between inflammation and cancer. Consistent with this, we previously showed that αβ T cell deficiency can increase resistance to chemical carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene and promoted by phorbol 12-myristate 13-acetate. This provoked the hypothesis that αβ T cell deficiency removed T ... More
CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis.
AuthorsNie CQ, Bernard NJ, Schofield L, Hansen DS,
JournalInfect Immun
PubMed ID17325053
'The infection of mice with Plasmodium berghei ANKA constitutes the best available mouse model for human Plasmodium falciparum-mediated cerebral malaria, a devastating neurological syndrome that kills nearly 2.5 million people every year. Experimental data suggest that cerebral disease results from the sequestration of parasitized erythrocytes within brain blood vessels, which ... More
A reduced antigen load in vivo, rather than weak inflammation, causes a substantial delay in CD8+ T cell priming against Mycobacterium bovis (bacillus Calmette-Guérin).
AuthorsRussell MS, Iskandar M, Mykytczuk OL, Nash JH, Krishnan L, Sad S,
JournalJ Immunol
PubMed ID17579040
Regardless of the dose of Ag, Ag presentation occurs rapidly within the first few days which results in rapid expansion of the CD8+ T cell response that peaks at day 7. However, we have previously shown that this rapid priming of CD8+ T cells is absent during infection of mice ... More