Evidence that bovine forebrain embryonic zinc finger-like gene influences immune response associated with mastitis resistance.
AuthorsSugimoto M,Fujikawa A,Womack JE,Sugimoto Y
JournalProceedings of the National Academy of Sciences of the United States of America
PubMed ID16611727
Mastitis, a mammary gland inflammation in response to bacterial infection, is a major problem in the dairy industry. We found that cows susceptible to mastitis have a three-base insertion in a glycine-coding stretch of the gene for forebrain embryonic zinc finger-like (FEZL), a transcription factor with a role in neuronal ... More
Calpain 3 is activated through autolysis within the active site and lyses sarcomeric and sarcolemmal components.
AuthorsTaveau M, Bourg N, Sillon G, Roudaut C, Bartoli M, Richard I,
JournalMol Cell Biol
PubMed ID14645524
Calpain 3 (Capn3) is known as the skeletal muscle-specific member of the calpains, a family of intracellular nonlysosomal cysteine proteases. This enigmatic protease has many unique features among the calpain family and, importantly, mutations in Capn3 have been shown to be responsible for limb girdle muscular dystrophy type 2A. Here ... More