Immune-like phagocyte activity in the social amoeba.
AuthorsChen G, Zhuchenko O, Kuspa A,
JournalScience
PubMed ID17673666
Social amoebae feed on bacteria in the soil but aggregate when starved to form a migrating slug. We describe a previously unknown cell type in the social amoeba, which appears to provide detoxification and immune-like functions and which we term sentinel (S) cells. S cells were observed to engulf bacteria ... More
Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.
AuthorsFonfria E, Clay WC, Levy DS, Goodwin JA, Roman S, Smith GD, Condreay JP, Michel AD,
JournalBr J Pharmacol
PubMed ID18037910
BACKGROUND AND PURPOSE: The human, rat, and mouse P2X(7) receptors have been previously characterized, and in this study we report the cloning and pharmacological properties of the guinea pig orthologue. EXPERIMENTAL APPROACH: A cDNA encoding for the guinea pig P2X(7) receptor was isolated from a guinea pig brain library. The ... More