High-sensitivity detection of DNA hybridization on microarrays using resonance light scattering.
Authors Bao Paul; Frutos Anthony G; Greef Charles; Lahiri Joydeep; Muller Uwe; Peterson Todd C; Warden Laurence; Xie Xinying;
JournalAnal Chem
PubMed ID11985309
The application of resonance light scattering (RLS) particles for high-sensitivity detection of DNA hybridization on cDNA microarrays is demonstrated. Arrays composed of approximately 2000 human genes ( ... More
The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes.
Authors Schübeler D; Groudine M; Bender M A;
JournalProc Natl Acad Sci U S A
PubMed ID11553791
Locus control regions (LCRs) are defined by their ability to confer high-level tissue-specific expression to linked genes in transgenic assays. Previously, we reported that, at its native site, the murine beta-globin LCR is required for high-level beta-globin gene expression, but is not required to initiate an open chromatin conformation of ... More