Peroxisome proliferator-activated receptor ß/d cross talks with E2F and attenuates mitosis in HRAS-expressing cells.
AuthorsZhu B, Khozoie C, Bility MT, Ferry CH, Blazanin N, Glick AB, Gonzalez FJ, Peters JM
JournalMol Cell Biol
PubMed ID22473992
'The role of peroxisome proliferator-activated receptor ß/d (PPARß/d) in Harvey sarcoma ras (Hras)-expressing cells was examined. Ligand activation of PPARß/d caused a negative selection with respect to cells expressing higher levels of the Hras oncogene by inducing a mitotic block. Mitosis-related genes that are predominantly regulated by E2F were induced ... More
Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.
AuthorsShi Y, Stefan CJ, Rue SM, Teis D, Emr SD
JournalMol Biol Cell
PubMed ID21880895
'Regulated secretion, nutrient uptake, and responses to extracellular signals depend on cell-surface proteins that are internalized and recycled back to the plasma membrane. However, the underlying mechanisms that govern membrane protein recycling to the cell surface are not fully known. Using a chemical-genetic screen in yeast, we show that the ... More
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
AuthorsBhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID22561460
We recently reported that integrin a(v)ß(3) is necessary for vascular barrier protection in mouse models of acute lung injury and peritonitis. Here, we used mass spectrometric sequencing of integrin complexes to isolate the novel ß(3)-integrin binding partner IQGAP1. Like integrin ß(3), IQGAP1 localized to the endothelial cell-cell junction after sphingosine-1-phosphate ... More