AuthorsLee SJ, Nam MJ, Lee DE, Park JW, Kang BS, Lee DS, Lee HS, Kwon OS
JournalInt J Mol Sci
PubMed ID30042374
'The mechanisms underlying the progression to non-alcoholic steatohepatitis (NASH) remain to be elucidated. In the present study, we aimed to identify the proteins involved in the pathogenesis of liver tissue inflammation and to investigate the effects of silibinin, a natural polyphenolic flavonoid, on steatohepatitis. We performed comparative proteomic analysis using ... More
Versican is differentially regulated in the adventitial and medial layers of human vein grafts.
AuthorsKenagy RD, Kikuchi S, Evanko SP, Ruiter MS, Piola M, Longchamp A, Pesce M, Soncini M, Deglise S, Fiore GB, Haefliger JA, Schmidt TA, Majesky MW, Sobel M, Wight TN
JournalPLoS One
PubMed ID30265729
'Changes in extracellular matrix proteins may contribute significantly to the adaptation of vein grafts to the arterial circulation. We examined the production and distribution of versican and hyaluronan in intact human vein rings cultured ex vivo, veins perfused ex vivo, and cultured venous adventitial and smooth muscle cells. Immunohistochemistry revealed ... More
The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes.
AuthorsBoudreault S, Armero VES, Scott MS, Perreault JP, Bisaillon M
JournalVirol J
PubMed ID30832682
'Alternative splicing (AS) is an important mRNA maturation step that allows increased variability and diversity of proteins in eukaryotes. AS is dysregulated in numerous diseases, and its implication in the carcinogenic process is well known. However, progress in understanding how oncogenic viruses modulate splicing, and how this modulation is involved ... More
PGC1ß regulates multiple myeloma tumor growth through LDHA-mediated glycolytic metabolism.
AuthorsZhang H, Li L, Chen Q, Li M, Feng J, Sun Y, Zhao R, Zhu Y, Lv Y, Zhu Z, Huang X, Xie W, Xiang W, Yao P
JournalMol Oncol
PubMed ID30051603
Multiple myeloma (MM) is an incurable hematologic malignancy due to inevitable relapse and chemoresistance development. Our preliminary data show that MM cells express high levels of PGC1ß and LDHA. In this study, we investigated the mechanism behind PGC1ß-mediated LDHA expression and its contribution to tumorigenesis, to aid in the development ... More
Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes.
AuthorsSaber MM, Al-Mahallawi AM, Nassar NN, Stork B, Shouman SA
JournalBMC Cancer
PubMed ID30111296
Colorectal cancer (CRC) remains a leading cause of death worldwide. Utilizing cisplatin in CRC is correlated with severe adverse effects and drug-resistance. Combined anticancer drug-treatment, along with, their enhanced delivery, can effectively kill cancer through multiple pathways. Nano-cubosomes are emerging as nanocarriers for anticancer therapies, hence, we constructed nano-cubosomes bearing ... More
An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea.
AuthorsSun M, Feng X, Liu Z, Han W, Liang YX, She Q
JournalNucleic Acids Res
PubMed ID29878182
While bacteria and eukaryotes show distinct mechanisms of DNA damage response (DDR) regulation, investigation of ultraviolet (UV)-responsive expression in a few archaea did not yield any conclusive evidence for an archaeal DDR regulatory network. Nevertheless, expression of Orc1-2, an ortholog of the archaeal origin recognition complex 1/cell division control protein 6 ... More
STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca
AuthorsPascual-Caro C, Berrocal M, Lopez-Guerrero AM, Alvarez-Barrientos A, Pozo-Guisado E, Gutierrez-Merino C, Mata AM, Martin-Romero FJ
JournalJ Mol Med (Berl)
PubMed ID30088035
STIM1 is an endoplasmic reticulum protein with a role in Ca
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.
AuthorsMcCarthy PC, Phair IR, Greger C, Pardali K, McGuire VA, Clark AR, Gaestel M, Arthur JSC
JournalImmunol Cell Biol
PubMed ID30171775
IL-33 is an IL-1-related cytokine that can act as an alarmin when released from necrotic cells. Once released, it can target various immune cells including mast cells, innate lymphoid cells and T cells to elicit a Th2-like immune response. We show here that bone marrow-derived mast cells produce IL-13, IL-6, ... More
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
AuthorsBryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, Diehl JN, Goode GD, Chaika NV, Wang Y, Zhang GF, Witkiewicz AK, Knudsen ES, Petricoin EF, Singh PK, Macdonald JM, Tran NL, Lyssiotis CA, Ying H, Kimmelman AC, Cox AD, Der CJ
JournalNat Med
PubMed ID30833752
Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS- and autophagy-dependent tumorigenic growth, but the role of KRAS in supporting autophagy has not been established. We show that, to our surprise, suppression of KRAS increased autophagic flux, as did pharmacological inhibition of its effector ERK MAPK. Furthermore, we demonstrate that either ... More
Statins Do Not Directly Inhibit the Activity of Major Epigenetic Modifying Enzymes.
The potential anticancer effects of statins-a widely used class of cholesterol lowering drugs-has generated significant interest, as has the use of epigenetic modifying drugs such as HDAC and DNMT inhibitors. We set out to investigate the effect of statin drugs on epigenetic modifications in multiple cell lines, including hepatocellular carcinoma, ... More