Pseudophosphorylation of tau protein alters its ability for self-aggregation.
AuthorsHaase C, Stieler JT, Arendt T, Holzer M,
JournalJ Neurochem
PubMed ID15009652
'Filamentous tau protein deposits are a pathological hallmark of a group of neurodegenerative disorders (tauopathies). Tau protein in these aggregates is highly phosphorylated at different phosphorylation sites. Although tau filaments can be formed by heparin-induced aggregation of unphosphorylated recombinant tau, it is not known how tau phosphorylation modulates aggregation behaviour. ... More
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
AuthorsYu Y, Run X, Liang Z, Li Y, Liu F, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX,
JournalJ Neurochem
PubMed ID19183272
Tau is a neuronal microtubule-associated protein. Its hyperphosphorylation plays a critical role in Alzheimer disease (AD). Expression and phosphorylation of tau are regulated developmentally, but its dynamic regulation and the responsible kinases or phosphatases remain elusive. Here, we studied the developmental regulation of tau in rats during development from embryonic ... More