Chlamydia trachomatis inclusions induce asymmetric cleavage furrow formation and ingression failure in host cells.
AuthorsSun HS, Wilde A, Harrison RE,
JournalMol Cell Biol
PubMed ID21969606
'Chlamydia trachomatis infection has been suggested to induce host genome duplication and is linked to increased risks of cervical cancer. We describe here the mechanism by which Chlamydia causes a cleavage furrow defect that consistently results in the formation of multinucleated host cells, a phenomenon linked to tumorigenesis. Host signaling ... More