JournalCellular and molecular life sciences : CMLS
PubMed ID37462735
Esophageal squamous cell carcinoma (ESCC) is a common malignancy worldwide with a low survival rate due to a lack of therapeutic targets. Here, our results showed that nuclear mitotic apparatus protein 1 (NUMA1) transcript and protein levels are significantly upregulated in ESCC patient samples and its high expression predicated poor ... More
A protein complex of LCN2, LOXL2 and MMP9 facilitates tumour metastasis in oesophageal cancer.
During malignant tumour development, the extracellular matrix (ECM) is usually abnormally regulated. Dysregulated expression of lysyl oxidase-like 2 (LOXL2), matrix metalloproteinase 9 (MMP9) and lipocalin 2 (LCN2) are associated with ECM remodelling. In this study, protein-protein interaction assays indicated that LCN2 and LOXL2 interactions and LCN2 and MMP9 interactions occurred ... More
RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin.
The small GTPase ARL8 associates with endolysosomes, leading to the recruitment of several effectors that couple endolysosomes to kinesins for anterograde transport along microtubules, and to tethering factors for eventual fusion with other organelles. Herein we report the identification of the RUN- and FYVE-domain-containing proteins RUFY3 and RUFY4 as ARL8 ... More
Immunoprecipitation Strategies to Isolate RIPK1/RIPK3 Complexes in Mouse Macrophages
AuthorsSiokas I, Zhang D, Poltorak A, Muendlein H, Degterev A
JournalCurr Protoc.
PubMed ID
Helicase-inactivating BRIP1 mutation yields Fanconi anemia with microcephaly and other congenital abnormalities
AuthorsKamal L, Pierce SB, Canavati C, Rayyan AA, Jaraysa T, Lobel O, Lolas S, Norquist BM, Rabie G, Zahdeh F, Levy-Lahad E, King M-C, Kanaan, MN
JournalCold Spring Harb Mol Case Stud
PubMed ID
A MAGEL2-deubiquitinase complex modulates the ubiquitination of circadian rhythm protein CRY1
Authors
JournalPLoS ONE
PubMed ID
GCN5 modulates salicylic acid homeostasis by regulating H3K14ac levels at the 5′ and 3′ ends of its target genes
AuthorsSoonkap Kim, Sophie J M Piquerez, Juan S Ramirez-Prado, Emmanouil Mastorakis, Alaguraj Veluchamy, David Latrasse, Deborah Manza-Mianza, Rim Brik-Chaouche, Ying Huang, Natalia Y Rodriguez-Granados, Lorenzo Concia, Thomas Blein, Sylvie Citerne, Abdelhafid Bendahmane, Catherine Bergounioux, Martin Crespi, Magdy M Mahfouz, Cécile Raynaud, Heribert Hirt, Vardis Ntoukakis, Moussa Benhamed
JournalNucleic Acids Research
PubMed ID
Shifting proteomes: limitations in using the BioID proximity labeling system to study SNARE protein trafficking during infection with intracellular pathogens