SID-1 Functions in Multiple Roles To Support Parental RNAi in Caenorhabditis elegans.
AuthorsWang E, Hunter CP,
JournalGenetics
PubMed ID28751423
'Systemic RNA interference (RNAi) in Caenorhbaditis elegans requires sid-1, sid-3, and sid-5 Injected, expressed, or ingested double-stranded RNA (dsRNA) is transported between cells, enabling RNAi in most tissues, including the germline and progeny (parental RNAi). A recent report claims that parental RNAi also requires the yolk receptor rme-2 Here, we ... More
FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts.
AuthorsSmith ER, Tan SJ, Holt SG, Hewitson TD,
JournalSci Rep
PubMed ID28611350
In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obstruction in the mouse, and pro-fibrotic actions of FGF23 on ... More