CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions.
AuthorsDevarakonda CV, Pereira FE, Smith JD, Shapiro LH, Ghosh M
JournalAtherosclerosis
PubMed ID31229835
'Atherosclerosis is an inflammatory cardiovascular disorder characterized by accumulation of lipid-loaded macrophages in the intima. Prolonged accumulation leads to apoptosis of macrophages and eventually to progression of lesion development. Prevention of macrophage accumulation within the intima has been shown to reduce lesion formation. Since CD13 mediates trafficking of macrophages to ... More
Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.
AuthorsSzulzewsky F, Schwendinger N, Güneykaya D, Cimino PJ, Hambardzumyan D, Synowitz M, Holland EC, Kettenmann H
JournalNeuro Oncol
PubMed ID29016864
'Microglia and periphery-derived monocytes infiltrate human and mouse glioblastoma and their density is positively correlated with malignancy. Using microarray and RNA sequencing, we have previously shown that glioblastoma-associated microglia/monocytes (GAMs) express osteopontin/SPP1.' ... More
Differential susceptibility of mouse strains on pancreatic injury and regeneration in cerulein-induced pancreatitis.
AuthorsZhang X, Shi Q, Wang C, Wang G
JournalInt J Clin Exp Pathol
PubMed ID31966883
'Acute pancreatitis (AP), a common disease, causes significant morbidity and mortality in clinical practice. Our objective of this study was to establish an experimental mouse AP model with cerulein treatment and to explore the susceptibility of mouse strains on the severity of pancreatic injury and the subsequent repair and regeneration. ... More
Tanshinone IIA promotes IL2-mediated SW480 colorectal cancer cell apoptosis by triggering INF2-related mitochondrial fission and activating the Mst1-Hippo pathway.
AuthorsQian J, Fang D, Lu H, Cao Y, Zhang J, Ding R, Li L, Huo J
JournalBiomed Pharmacother
PubMed ID30372868
IL-2-based therapy is a promising tool to treat colorectal cancer, but drug resistance always occurs in clinical practice. Mitochondrial fission is a novel target to modulate cancer development and progression. The aim of our study is to explore the effect of IL-2 combined with Tan IIA on SW480 colorectal cancer ... More
Sirtuin-1 protects hair follicle stem cells from TNFa-mediated inflammatory stress via activating the MAPK-ERK-Mfn2 pathway.
AuthorsLiu J, Xu Y, Wu Q, Ding Q, Fan W
JournalLife Sci
PubMed ID30292830
Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFa-mediated inflammatory stress in hair ... More
Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p.
AuthorsCai B, Wang X, Liu H, Ma S, Zhang K, Zhang Y, Li Q, Wang J, Yao M, Guan F, Yin G
JournalCell Cycle
PubMed ID31203719
Hair follicle stem cells (HFSCs), located in the bulge region of the follicle, maintain hair follicle growth and cycling. Long non-coding RNAs (lncRNAs), non-protein coding transcripts, are widely known to play critical roles in differentiation and proliferation of stem cells. Therefore, the current study aimed to explore the regulatory roles ... More
YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling.
AuthorsKegelman CD, Coulombe JC, Jordan KM, Horan DJ, Qin L, Robling AG, Ferguson VL, Bellido TM, Boerckel JD
JournalJ Bone Miner Res
PubMed ID31610061
Bone fragility fractures are caused by low bone mass or impaired bone quality. Osteoblast/osteoclast coordination determines bone mass, but the factors that control bone quality are poorly understood. Osteocytes regulate osteoblast and osteoclast activity on bone surfaces but can also directly reorganize the bone matrix to improve bone quality through ... More
Neonatal ethanol exposure triggers apoptosis in the murine retrosplenial cortex: Role of inhibition of NMDA receptor-driven action potential firing.
Exposure to ethanol during the last trimester equivalent of human pregnancy causes apoptotic neurodegeneration in the developing brain, an effect that is thought to be mediated, in part, by inhibition of NMDA receptors. However, NMDA receptors can rapidly adapt to the acute effects of ethanol and are ethanol resistant in ... More
Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice.
AuthorsTsuji S, Di Martino E, Mukai T, Tsuji S, Murakami T, Harris RA, Blomgren K, Åden U
JournalJ Neuroinflammation
PubMed ID32276642
Neuroinflammation plays an important role in neonatal hypoxic-ischemic encephalopathy (HIE). Although microglia are largely responsible for injury-induced inflammatory response, they play beneficial roles in both normal and disease states. However, the effects of microglial depletion on neonatal HIE remain unclear. ... More