Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons.
AuthorsMaroteaux M, Mameli M,
JournalJ Neurosci
PubMed ID22956853
Addictive drugs share the ability to increase dopamine (DA) levels and trigger synaptic adaptations in the mesocorticolimbic system, two cellular processes engaged in the early stages of drug seeking. Neurons located in the lateral habenula (LHb) modulate the activity of DA neurons and DA release, and adaptively tune goal-directed behaviors. ... More
Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation.
AuthorsKowalski MP, Pier GB
JournalJ Immunol
PubMed ID14688350
'The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein is an epithelial cell receptor for the outer core oligosaccharide of the Pseudomonas aeruginosa LPS. Bacterial binding leads to CFTR-dependent bacterial internalization, initiation of NF-kappaB nuclear translocation, cellular desquamation, and eventual apoptosis of the infected cells, all of which are critical ... More
Chondrocytes utilize a cholesterol-dependent lipid translocator to externalize phosphatidylserine.
AuthorsDamek-Poprawa M, Golub E, Otis L, Harrison G, Phillips C, Boesze-Battaglia K
JournalBiochemistry
PubMed ID16519527
'During endochondral ossification, growth plate chondrocytes release plasma membrane (PM) derived matrix vesicles (MV), which are the site of initial hydroxyapatite crystal formation. MV constituents which facilitate the mineralization process include the integral membrane ectoenzymes alkaline phosphatase (ALPase) and nucleotide pyrophosphatase phosphodiesterase (NPP1/PC-1), along with a phosphatidylserine- (PS-) rich membrane ... More
Inhibition of caveolar uptake, SV40 infection, and beta1-integrin signaling by a nonnatural glycosphingolipid stereoisomer.
AuthorsSingh RD, Holicky EL, Cheng ZJ, Kim SY, Wheatley CL, Marks DL, Bittman R, Pagano RE
JournalJ Cell Biol
PubMed ID17371832
'Caveolar endocytosis is an important mechanism for the uptake of certain pathogens and toxins and also plays a role in the internalization of some plasma membrane (PM) lipids and proteins. However, the regulation of caveolar endocytosis is not well understood. We previously demonstrated that caveolar endocytosis and beta1-integrin signaling are ... More
Plasticity of B cell receptor internalization upon conditional depletion of clathrin.
AuthorsStoddart A, Jackson AP, Brodsky FM
JournalMol Biol Cell
PubMed ID15716350
'B cell antigen receptor (BCR) association with lipid rafts, the actin cytoskeleton, and clathrin-coated pits influences B cell signaling and antigen presentation. Although all three cellular structures have been separately implicated in BCR internalization, the relationship between them has not been clearly defined. In this study, internalization pathways were characterized ... More
Condensed complexes, rafts, and the chemical activity of cholesterol in membranes.
AuthorsRadhakrishnan A, Anderson TG, McConnell HM
JournalProc Natl Acad Sci U S A
PubMed ID11050164
'Epifluorescence microscopy studies of mixtures of phospholipids and cholesterol at the air-water interface often exhibit coexisting liquid phases. The properties of these liquids point to the formation of "condensed complexes" between cholesterol and certain phospholipids, such as sphingomyelin. It is found that monolayers that form complexes can incorporate a low ... More
Early and rapid targeting of eye-specific axonal projections to the dorsal lateral geniculate nucleus in the fetal macaque.
AuthorsHuberman AD, Dehay C, Berland M, Chalupa LM, Kennedy H
JournalJ Neurosci
PubMed ID15843603
'The emergence of eye-specific axonal projections to the dorsal lateral geniculate nucleus (dLGN) is a well established model system for exploring the mechanisms underlying afferent targeting during development. Using modern tract tracing methods, we examined the development of this feature in the macaque, an Old World Primate with a visual ... More
Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation.
AuthorsOray S, Majewska A, Sur M
JournalNeuron
PubMed ID15603744
'The mammalian primary visual cortex (V1) is especially susceptible to changes in visual input over a well-defined critical period, during which closing one eye leads to a loss of responsiveness of neurons to the deprived eye and a shift in response toward the open eye. This functional plasticity can occur ... More
A neural circuit for memory specificity and generalization.
AuthorsXu W, Südhof TC,
JournalScience
PubMed ID23493706
'Increased fear memory generalization is associated with posttraumatic stress disorder, but the circuit mechanisms that regulate memory specificity remain unclear. Here, we define a neural circuit-composed of the medial prefrontal cortex, the nucleus reuniens (NR), and the hippocampus-that controls fear memory generalization. Inactivation of prefrontal inputs into the NR or ... More
AuthorsSteinert S, Lee E, Tresset G, Zhang D, Hortsch R, Wetzel R, Hebbar S, Sundram JR, Kesavapany S, Boschke E, Kraut R,
JournalPLoS ONE
PubMed ID18716682
'BACKGROUND: The uptake and intracellular trafficking of sphingolipids, which self-associate into plasma membrane microdomains, is associated with many pathological conditions, including viral and toxin infection, lipid storage disease, and neurodegenerative disease. However, the means available to label the trafficking pathways of sphingolipids in live cells are extremely limited. In order ... More
Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering.
AuthorsFassett MS, Davis DM, Valter MM, Cohen GB, Strominger JL
JournalProc Natl Acad Sci U S A
PubMed ID11724921
'Natural killer (NK) cell cytotoxicity is determined by a balance of positive and negative signals. Negative signals are transmitted by NK inhibitory receptors (killer immunoglobulin-like receptors, KIR) at the site of membrane apposition between an NK cell and a target cell, where inhibitory receptors become clustered with class I MHC ... More
Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons.
AuthorsSoundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VF
JournalJ Neurosci
PubMed ID16554476
'Embryonic stem (ES) cells differentiate into functional motoneurons when treated with a sonic hedgehog (Shh) agonist and retinoic acid (RA). Whether ES cells can be directed to differentiate into specific subtypes of motoneurons is unknown. We treated embryoid bodies generated from HBG3 ES cells with a Shh agonist and RA ... More
Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping.
'In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were ... More
Glucoprivation in the ventrolateral medulla decreases brown adipose tissue sympathetic nerve activity by decreasing the activity of neurons in raphe pallidus.
AuthorsMadden CJ,
JournalAm J Physiol Regul Integr Comp Physiol
PubMed ID22071154
'In urethane/a-chloralose anesthetized rats, cold exposure increased brown adipose tissue sympathetic nerve activity (BAT SNA: +699 ± 104% control). Intravenous administration of 2-deoxy-D-glucose (2-DG; 200 mg·ml(-1)·kg(-1)) reversed the cold-evoked activation of BAT SNA (nadir: 139 ± 36% of control) and decreased BAT temperature (-1.1 ± 0.2°C), expired CO(2) (-0.4 ± ... More
The efficacy of the fluorescent conjugates of cholera toxin subunit B for multiple retrograde tract tracing in the central nervous system.
AuthorsConte WL, Kamishina H, Reep RL,
JournalBrain Struct Funct
PubMed ID19621243
'Cholera toxin subunit B (CTB) is a sensitive neuroanatomical tracer that generally transports retrogradely in the nervous system, and has been used extensively in brightfield microscopy. Recently, Alexa Fluor (AF) conjugates of CTB have been made available, which now allows multiple tracing with CTB. In this study, we examined the ... More
Crossed and uncrossed retinal projections to the hamster circadian system.
AuthorsMuscat L, Huberman AD, Jordan CL, Morin LP
JournalJ Comp Neurol
PubMed ID14566946
'The hamster suprachiasmatic nucleus (SCN), site of the circadian clock, has been thought to be equally and completely innervated by each retina. This issue was studied in animals that had received an injection of the tracer cholera toxin subunit B (CTb) conjugated to Alexa 488 into the vitreous of one ... More
Spontaneous activity promotes synapse formation in a cell-type-dependent manner in the developing retina.
AuthorsSoto F, Ma X, Cecil JL, Vo BQ, Culican SM, Kerschensteiner D,
JournalJ Neurosci
PubMed ID22514306
'Spontaneous activity is thought to regulate synaptogenesis in many parts of the developing nervous system. In vivo evidence for this regulation, however, is scarce and comes almost exclusively from experiments in which normal activity was reduced or blocked completely. Thus, whether spontaneous activity itself promotes synaptogenesis or plays a purely ... More
ClearT: a detergent- and solvent-free clearing method for neuronal and non-neuronal tissue.
We describe a clearing method for enhanced visualization of cell morphology and connections in neuronal and non-neuronal tissue. Using Clear(T) or Clear(T2), which are composed of formamide or formamide/polyethylene glycol, respectively, embryos, whole mounts and thick brain sections can be rapidly cleared with minimal volume changes. Unlike other available clearing ... More
Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88.
AuthorsNishiya T, Kajita E, Horinouchi T, Nishimoto A, Miwa S,
JournalFEBS Lett
PubMed ID17583698
MyD88 is a cytoplasmic adaptor protein that is critical for Toll-like receptor (TLR) signaling. The subcellular localization of MyD88 is characterized as large condensed forms in the cytoplasm. The mechanism and significance of this localization with respect to the signaling function, however, are currently unknown. Here, we demonstrate that MyD88 ... More
Multiple neuroanatomical tract-tracing using fluorescent Alexa Fluor conjugates of cholera toxin subunit B in rats.
AuthorsConte WL, Kamishina H, Reep RL,
JournalNat Protoc
PubMed ID19617887
Cholera toxin subunit B (CTB) is a highly sensitive retrograde neuroanatomical tracer. With the new availability of fluorescent Alexa Fluor (AF) conjugates of CTB, multiple neuroanatomical connections can be reliably studied and compared in the same animal. Here we provide a protocol that describes the use of AF-CTB for studying ... More
High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections.
AuthorsTorborg CL, Hansen KA, Feller MB
JournalNat Neurosci
PubMed ID15608630
Blockade of retinal waves prevents the segregation of retinogeniculate afferents into eye-specific layers in the visual thalamus. However, the key features of retinal waves that drive this refinement are controversial. Some manipulations of retinal waves lead to normal eye-specific segregation but others do not. By comparing retinal spiking patterns in ... More
Vav family GEFs link activated Ephs to endocytosis and axon guidance.
AuthorsCowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME
JournalNeuron
PubMed ID15848800
Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. We ... More
Orthobunyavirus entry into neurons and other mammalian cells occurs via clathrin-mediated endocytosis and requires trafficking into early endosomes.
La Crosse virus (LACV) is a leading cause of pediatric encephalitis and aseptic meningitis in the midwestern and southern United States, where it is considered an emerging human pathogen. No specific therapies or vaccines are available for LACV or any other orthobunyaviruses. Inhibition of LACV entry into cells is a ... More
Role of lipid rafts and flagellin in invasion of colonic epithelial cells by Shiga-toxigenic Escherichia coli O113:H21.
AuthorsRogers TJ, Thorpe CM, Paton AW, Paton JC,
JournalInfect Immun
PubMed ID22689816
Shiga-toxigenic Escherichia coli (STEC) O113:H21 strains that lack the locus of enterocyte effacement (LEE) efficiently invade eukaryotic cells in vitro, unlike LEE-positive O157:H7 strains. We used a fliC deletion mutant of the O113:H21 STEC strain 98NK2 (98NK2?fliC) to show that invasion of colonic epithelial (HCT-8) cells is heavily dependent on ... More
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.
AuthorsWatkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW,
JournalProc Natl Acad Sci U S A
PubMed ID23431164
The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. Here we show that the mixed-lineage dual leucine zipper kinase (DLK) is an essential upstream mediator of both of these divergent outcomes in the same cell type. Optic ... More
Connectional heterogeneity of the ventral part of the macaque area 46.
AuthorsGerbella M, Borra E, Tonelli S, Rozzi S, Luppino G,
JournalCereb Cortex
PubMed ID22499799
We found that the ventral part of the prefrontal area 46 (46v) is connectionally heterogeneous. Specifically, the rostral part (46vr) displayed an almost exclusive and extensive intraprefrontal connectivity and extraprefrontal connections limited to area 24 and inferotemporal areas. In contrast, the caudal part (46vc) mostly displayed intraprefrontal connectivity with ventrolateral ... More
The zebra finch paradox: song is little changed, but number of neurons doubles.
AuthorsWalton C, Pariser E, Nottebohm F,
JournalJ Neurosci
PubMed ID22262875
New neurons are added to the high vocal center (HVC) of adult males in seasonally breeding songbirds such as the canary (Serinus canaria) that learns new songs in adulthood, and the song sparrow (Melospiza melodia) that does not. In both cases, the new neurons numerically replace others that have died, ... More
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale.
AuthorsBohland JW, Wu C, Barbas H, Bokil H, Bota M, Breiter HC, Cline HT, Doyle JC, Freed PJ, Greenspan RJ, Haber SN, Hawrylycz M, Herrera DG, Hilgetag CC, Huang ZJ, Jones A, Jones EG, Karten HJ, Kleinfeld D, Kötter R, Lester HA, Lin JM, Mensh BD, Mikula S, Panksepp J, Price JL, Safdieh J, Saper CB, Schiff ND, Schmahmann JD, Stillman BW, Svoboda K, Swanson LW, Toga AW, Van Essen DC, Watson JD, Mitra PP,
JournalPLoS Comput Biol
PubMed ID19325892
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale ... More
The utilization of pathogen-like cellular trafficking by single chain block copolymer.
Amphiphilic triblock copolymer, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Pluronic P85, is unexpectedly shown to utilize sophisticated cellular trafficking mechanisms and enter brain microvessel endothelial cells and primary neurons that are poorly penetrable. Though caveolae serve as a primary entry site for the copolymer single chains, in cells devoid of caveolae, the ... More
Invariant computations in local cortical networks with balanced excitation and inhibition.
AuthorsMariño J, Schummers J, Lyon DC, Schwabe L, Beck O, Wiesing P, Obermayer K, Sur M
JournalNat Neurosci
PubMed ID15665876
Cortical computations critically involve local neuronal circuits. The computations are often invariant across a cortical area yet are carried out by networks that can vary widely within an area according to its functional architecture. Here we demonstrate a mechanism by which orientation selectivity is computed invariantly in cat primary visual ... More
Evidence for neurogenesis in the adult mammalian substantia nigra.
AuthorsZhao M, Momma S, Delfani K, Carlen M, Cassidy RM, Johansson CB, Brismar H, Shupliakov O, Frisen J, Janson AM
JournalProc Natl Acad Sci U S A
PubMed ID12792021
New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of ... More
AuthorsKultti A, Rilla K, Tiihonen R, Spicer AP, Tammi RH, Tammi MI
JournalJ Biol Chem
PubMed ID16595683
Hyaluronan synthases (HASs) are plasma membrane enzymes that simultaneously elongate, bind, and extrude the growing hyaluronan chain directly into extracellular space. In cells transfected with green fluorescent protein (GFP)-tagged Has3, the dorsal surface was decorated by up to 150 slender, 3-20-microm-long microvillus-type plasma membrane protrusions, which also contained filamentous actin, ... More
Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI.
AuthorsNieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T
JournalProc Natl Acad Sci U S A
PubMed ID12438696
The high-density lipoprotein (HDL) receptor, scavenger receptor, class B, type I (SR-BI), mediates both the selective uptake of lipids, mainly cholesterol esters, from HDL to cells and the efflux of cholesterol from cells to lipoproteins. The mechanism underlying these lipid transfers is distinct from classic receptor-mediated endocytosis, but it remains ... More
Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5.
AuthorsNguyen DH, Taub D
JournalBlood
PubMed ID12036855
The chemokine receptor, CCR5, is used as a human immunodeficiency virus coreceptor in combination with CD4 during transmission and early infection. CCR5 has been shown to be palmitoylated and targeted to cholesterol- and sphingolipid-rich membrane microdomains termed "lipid rafts." However, the role of cholesterol and lipid rafts on chemokine binding ... More
Anti-glycosyl antibodies in lipid rafts of the enterocyte brush border: a possible host defense against pathogens.
AuthorsHansen GH, Pedersen ED, Immerdal L, Niels-Christiansen LL, Danielsen EM
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID16081758
The pig small intestinal brush border is a glycoprotein- and glycolipid-rich membrane that functions as a digestive/absorptive surface for dietary nutrients as well as a permeability barrier for pathogens. The present work was performed to identify carbohydrate-binding (lectinlike) proteins associated with the brush border. Chromatography on lactose-agarose was used to ... More
Remodeling of synaptic structure in sensory cortical areas in vivo.
AuthorsMajewska AK, Newton JR, Sur M
JournalJ Neurosci
PubMed ID16540580
Although plastic changes are known to occur in developing and adult cortex, it remains unclear whether these changes require remodeling of cortical circuitry whereby synapses are formed and eliminated or whether they rely on changes in the strength of existing synapses. To determine the structural stability of dendritic spines and ... More
Identification of a novel apical sorting motif and mechanism of targeting of the M2 muscarinic acetylcholine receptor.
AuthorsChmelar RS, Nathanson NM
JournalJ Biol Chem
PubMed ID16968700
Previous studies have shown that the M2 receptor is localized at steady state to the apical domain in Madin-Darby canine kidney (MDCK) epithelial cells. In this study, we identify the molecular determinants governing the localization and the route of apical delivery of the M2 receptor. First, by confocal analysis of ... More
The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis.
AuthorsSandgren S, Wittrup A, Cheng F, Jönsson M, Eklund E, Busch S, Belting M
JournalJ Biol Chem
PubMed ID14963039
Antimicrobial peptides, such as LL-37, are found both in nonvertebrates and vertebrates, where they represent important components of innate immunity. Bacterial infections at epithelial surfaces are associated with substantial induction of LL-37 expression, which allows efficient lysis of the invading microbes. Peptide-mediated lysis results in the release of bacterial nucleic ... More
Localization and regulation of thyrotropin receptors within lipid rafts.
AuthorsLatif R, Ando T, Daniel S, Davies TF
JournalEndocrinology
PubMed ID12960014
The TSH receptor (TSHR) is a prototypic G protein-coupled receptor with a large extracellular domain. We have previously demonstrated homophilic interactions of TSHRs and their existence as constitutive oligomers. However, we have also shown that TSH itself promotes the formation of receptor monomers. We hypothesized, therefore, that TSHR monomers induced ... More
Cellular uptake of exogenous human PDCD5 protein.
AuthorsWang Y, Li D, Fan H, Tian L, Zhong Y, Zhang Y, Yuan L, Jin C, Yin C, Ma D
JournalJ Biol Chem
PubMed ID16754680
PDCD5 (human programmed cell death 5) plays a significant role in apoptotic and paraptotic cell deaths. However, it was found that recombinant PDCD5 added exogenously to culture medium could also enhance programmed cell death triggered by certain stimuli. Here we show that PDCD5 has a remarkable role in intercellular transport ... More
CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4.
AuthorsPopik W, Alce TM
JournalJ Biol Chem
PubMed ID14570906
Despite the preferential localization of CD4 to lipid rafts, the significance and role of these microdomains in HIV-1 entry is still controversial. The possibility that CD4, when localized to non-raft domains, might be able to support virus entry cannot be excluded. Because disintegration of rafts by extraction of cellular cholesterol ... More
Decoding the entry of two novel cell-penetrating peptides in HeLa cells: lipid raft-mediated endocytosis and endosomal escape.
AuthorsFoerg C, Ziegler U, Fernandez-Carneado J, Giralt E, Rennert R, Beck-Sickinger AG, Merkle HP
JournalBiochemistry
PubMed ID15628847
Cellular entry of peptide, protein, and nucleic acid biopharmaceuticals is severely impeded by the cell membrane. Linkage or assembly of such agents and cell-penetrating peptides (CPP) with the ability to cross cellular membranes has opened a new horizon in biomedical research. Nevertheless, the uptake mechanisms of most CPP have been ... More
Increased anxiety and decreased sociability induced by paternal deprivation involve the PVN-PrL OTergic pathway.
AuthorsHe Z, Young L, Ma XM, Guo Q, Wang L, Yang Y, Luo L, Yuan W, Li L, Zhang J, Hou W, Qiao H, Jia R, Tai F
JournalElife
PubMed ID31084703
'Early adverse experiences often have devastating consequences. However, whether preweaning paternal deprivation (PD) affects emotional and social behaviors and their underlying neural mechanisms remain unexplored. Using monogamous mandarin voles, we found that PD increased anxiety-like behavior and attenuated social preference in adulthood. PD also decreased the number of oxytocin (OT)-positive ... More
Impact of Graphene on the Efficacy of Neuron Culture Substrates.
Authors
JournalAdv Healthc Mater
PubMed ID29943431
ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.
AuthorsViaud M, Abdel-Wahab O, Gall J, Ivanov S, Guinamard R, Sore S, Merlin J, Ayrault M, Guilbaud E, Jacquel A, Auberger P, Wang N, Levine RL, Tall AR, Yvan-Charvet L
JournalCell Rep
PubMed ID32160545
'Defective cholesterol efflux pathways in mice promote the expansion of hematopoietic stem and progenitor cells and a bias toward the myeloid lineage, as observed in chronic myelomonocytic leukemia (CMML). Here, we identify 5 somatic missense mutations in ABCA1 in 26 patients with CMML. These mutations confer a proliferative advantage to ... More
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
Authors
JournalJ Exp Med
PubMed ID32860705
Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains.
Authors
JournalNeuron
PubMed ID29706584
DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis.
Authors
JournalNat Commun
PubMed ID34620861
Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission.
Authors
JournalNeuron
PubMed ID28426970
Visual intracortical and transthalamic pathways carry distinct information to cortical areas.
Authors
JournalNeuron
PubMed ID33979633
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins.
Authors
JournalNat Immunol
PubMed ID32514064
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
Authors
JournalProc Natl Acad Sci U S A
PubMed ID33239446
Neuropathic pain caused by miswiring and abnormal end organ targeting.
Authors
JournalNature
PubMed ID35614217
Segregated Subnetworks of Intracortical Projection Neurons in Primary Visual Cortex.
The rules by which neurons in neocortex choose their synaptic partners are not fully understood. In sensory cortex, intermingled neurons encode different attributes of sensory inputs and relay them to different long-range targets. While neurons with similar responses to sensory stimuli make connections preferentially, the relationship between synaptic connectivity within ... More
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits.
AuthorsAn JJ, Kinney CE, Tan JW, Liao GY, Kremer EJ, Xu B
JournalNat Commun
PubMed ID32265438
The TrkB receptor is critical for the control of energy balance, as mutations in its gene (NTRK2) lead to hyperphagia and severe obesity. The main neural substrate mediating the appetite-suppressing activity of TrkB, however, remains unknown. Here, we demonstrate that selective Ntrk2 deletion within paraventricular hypothalamus (PVH) leads to severe ... More
The gut-brain axis mediates sugar preference.
AuthorsTan HE, Sisti AC, Jin H, Vignovich M, Villavicencio M, Tsang KS, Goffer Y, Zuker CS
JournalNature
PubMed ID32322067
The taste of sugar is one of the most basic sensory percepts for humans and other animals. Animals can develop a strong preference for sugar even if they lack sweet taste receptors, indicating a mechanism independent of taste ... More