Imaging EGFR phosphorylation in intact human pancreatic carcinoma cells.
AuthorsMagdeburg R, Kessler M, Boenninghoff R, Keese M,
JournalIn Vivo
PubMed ID22773576
'Carcinoma of the pancreatic duct is a highly malignant tumor characterized by aggressive and early metastastatic growth. A high rate of tumor recurrence after surgical resection and the lack of effective chemotherapeutic approaches result in low 5-year survival rates. Overexpression of epidermal growth factor (EGF) and its receptor have been ... More
Induction of apoptosis pathways in several cell lines following exposure to the marine algal toxin azaspiracid.
'Azaspiracids (AZAs) are polyether marine dinoflagellate toxins that accumulate in shellfish and represent an emerging human health risk. Although there have been no deaths associated with the AZA toxins, humans exposed to AZAs experience severe gastrointestinal symptoms. This toxin class has been shown to be highly cytotoxic, a teratogen to ... More
Subtoxic levels hydrogen peroxide-induced production of interleukin-6 by retinal pigment epithelial cells.
AuthorsWu WC, Hu DN, Gao HX, Chen M, Wang D, Rosen R, McCormick SA
JournalMol Vis
PubMed ID21031020
To study the effect of subtoxic levels of hydrogen peroxide (H(2)O(2)) on the expression and release of interleukin-6 (IL-6) by cultured retinal pigment epithelial (RPE) cells and to explore the relevant signal pathways. ... More
Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway.
AuthorsHu DN, Chen M, Zhang DY, Ye F, McCormick SA, Chan CC
JournalInvest Ophthalmol Vis Sci
PubMed ID21398280
Melanocyte is the major cell component in the uvea. Interleukin (IL)-6 is a proinflammatory cytokine. The authors studied the expression of IL-6 in cultured human uveal melanocytes (UMs) and their modulation by IL-1ß and explored the relevant signal pathways. ... More
Twist modulates human trophoblastic cell invasion via regulation of N-cadherin.
AuthorsNg YH, Zhu H, Leung PC
JournalEndocrinology
PubMed ID22166980
The invasion of extravillous cytotrophoblasts (EVT) into the underlying maternal tissues and vasculature is a key step in human placentation. The molecular mechanisms involved in the development of the invasive phenotype of EVT include many that were first discovered for their role in cancer cell metastasis. Previous studies have demonstrated ... More
GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.
AuthorsWallin JJ, Edgar KA, Guan J, Berry M, Prior WW, Lee L, Lesnick JD, Lewis C, Nonomiya J, Pang J, Salphati L, Olivero AG, Sutherlin DP, O'Brien C, Spoerke JM, Patel S, Lensun L, Kassees R, Ross L, Lackner MR, Sampath D, Belvin M, Friedman LS
JournalMol Cancer Ther
PubMed ID21998291
Alterations of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway occur broadly in cancer via multiple mechanisms including mutation of the PIK3CA gene, loss or mutation of phosphatase and tensin homolog (PTEN), and deregulation of mammalian target of rapamycin (mTOR) complexes. The dysregulation of this pathway has been implicated in tumor initiation, ... More