Cleavage of hyaluronan is impaired in aged dermal wounds.
AuthorsReed MJ, Damodarasamy M, Chan CK, Johnson MN, Wight TN, Vernon RB,
JournalMatrix Biol
PubMed ID23022999
'Changes in extracellular matrix (ECM) are one of many components that contribute to impaired wound healing in aging. This study examined the effect of age on the glycosaminoglycan hyaluronan (HA) in normal and wounded dermis from young (4-6 month-old) and aged (22-24 month-old) mice. HA content and size were similar ... More
Thyroid hormone controls the gene expression of HSV-1 LAT and ICP0 in neuronal cells.
'Various factors/pathways including hormonal regulation have been suggested to control herpes simplex virus type 1 (HSV-1) latency and reactivation. Our computer analysis identified a DNA repeat containing thyroid hormone-responsive elements (TRE) in the regulatory region of HSV-1 latency-associated transcript (LAT). Thyroid hormone (triiodothyronine, T(3)) functions via its receptor TR (thyroid ... More
miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression.
AuthorsSalim H, Arvanitis A, de Petris L, Kanter L, Hååg P, Zovko A, Özata DM, Lui WO, Lundholm L, Zhivotovsky B, Lewensohn R, Viktorsson K,
Journal
PubMed ID23929716
'The prognosis of non-small cell lung cancer (NSCLC) is poor, since it has often metastasized to distant organs by the time of diagnosis. Therefore, biomarkers predicting metastasis are crucial. miRNAs play important roles in the regulation of different tumor cell processes, including metastasis. We recently showed that miRNA-214 is linked ... More
miR-205 expression promotes cell proliferation and migration of human cervical cancer cells.
AuthorsXie H, Zhao Y, Caramuta S, Larsson C, Lui WO,
JournalPLoS One
PubMed ID23056551
MicroRNAs (miRNAs) are short non-coding RNA regulators that control gene expression mainly through post-transcriptional silencing. We previously identified miR-205 in a signature for human cervical cancer using a deep sequencing approach. In this study, we confirmed that miR-205 expression was frequently higher in human cervical cancer than their matched normal ... More
A preclinical assessment of neural stem cells as delivery vehicles for anti-amyloid therapeutics.
AuthorsNjie eG, Kantorovich S, Astary GW, Green C, Zheng T, Semple-Rowland SL, Steindler DA, Sarntinoranont M, Streit WJ, Borchelt DR,
JournalPLoS One
PubMed ID22496779
Transplantation of neural stems cells (NSCs) could be a useful means to deliver biologic therapeutics for late-stage Alzheimer's disease (AD). In this study, we conducted a small preclinical investigation of whether NSCs could be modified to express metalloproteinase 9 (MMP9), a secreted protease reported to degrade aggregated Aß peptides that ... More
Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats.
AuthorsWilliams DB, Wan Z, Frier BC, Bell RC, Field CJ, Wright DC,
JournalAm J Physiol Regul Integr Comp Physiol
PubMed ID22031784
Glucocorticoid excess induces marked insulin resistance and glucose intolerance. A recent study has shown that antioxidants prevent dexamethasone (DEX)-induced insulin resistance in cultured adipocytes. The purpose of this investigation was to examine the effects of dietary vitamin E and C (Vit E/C) supplementation on DEX-induced glucose intolerance in rats. We ... More
The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma.
AuthorsÖzata DM, Caramuta S, Velázquez-Fernández D, Akçakaya P, Xie H, Höög A, Zedenius J, Bäckdahl M, Larsson C, Lui WO,
JournalEndocr Relat Cancer
PubMed ID21859927
Adrenocortical carcinoma (ACC) is an aggressive tumor showing frequent metastatic spread and poor survival. Although recent genome-wide studies of ACC have contributed to our understanding of the disease, major challenges remain for both diagnostic and prognostic assessments. The aim of this study was to identify specific microRNAs (miRNAs) associated with ... More
VEGF/VEGFR-2 changes in frontal cortex, choroid plexus, and CSF after chronic obstructive hydrocephalus.
AuthorsYang J, Dombrowski SM, Deshpande A, Krajcir N, Luciano MG,
JournalJ Neurol Sci
PubMed ID20619858
Chronic hydrocephalus (CH) is often associated with decreased cerebral blood flow (CBF) and oxygen levels. While the exact pathophysiology is not clear, vascular endothelial growth factor (VEGF) and its receptor-2 (VEGFR-2) may be involved. Because the choroid plexus (CP) is involved in cerebrospinal fluid (CSF) production and secretes numerous growth ... More