引用和文献 (6)

Invitrogen™

胎儿血红蛋白检测试剂盒，FITC

货号	数量
HFH01	100 次测试

货号 HFH01

价格（CNY)

6,054.00

Ends: 31-Dec-2026

8,044.00

共减 1,990.00 (25%)

100 次测试

价格（CNY)

6,054.00

Ends: 31-Dec-2026

8,044.00

共减 1,990.00 (25%)

The Fetal Hemoglobin (HbF) Test is based on a monoclonal antibody directed to fetal hemoglobin (hemoglobin F). This antibody is conjugated with fluorescein (FITC). Commonly used, the fluorescein conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.

This reagent is intended for the identification followed by enumeration of fetal red blood cells. Fetal cells are identified by the presence of fetal hemoglobin using a flow cytometric method. The Fetal Hemoglobin Test may be used as an aid in identifying fetal-maternal hemorrhage and determining the need for immunoprophylaxis with immune globulin.

胎血红蛋白 (HbF) 检测基于直接用于胎儿血红蛋白（血红蛋白 F）的单克隆抗体。该抗体与荧光素 (FITC) 结合。常用的荧光素偶联物具有相对高的吸收率、出色的荧光量子产率和良好的水溶性。

该试剂专门用于鉴定胎儿红细胞，然后对其进行计数。使用流式细胞仪检测是否存在胎儿血红蛋白来鉴定胎儿细胞。胎儿血红蛋白检测可用作确定胎儿母血出血的辅助工具，并确定是否需要免疫球蛋白免疫预防。

抗体规格

描述：胎儿血红蛋白 F (HbF)，小鼠 IgG1 单克隆
标签：荧光素 (FITC)
经验证的应用：流式细胞分析
物种反应性：人
激发/发射波长与激光配置：488/519 nm，蓝色激光
克隆 ID：HbF-1

抗体特性包括：

临床相关性
胎儿血红蛋白检测包含定向至 HbF 的单克隆抗体，其可特异性识别胎儿红细胞中的胎儿血红蛋白。该测试允许通过胎儿母体出血或胎儿细胞泄漏进入母体循环来枚举母体中的胎儿红细胞。Rh+ 胎儿的细胞出血进入 Rh- 母亲的循环，则可能导致母亲产生 Rh 反应抗体。随后的 Rh+ 胎儿 Rh 溶血性贫血可能导致胎盘中母体形成的抗体向胎儿的转移。尽管怀孕期间和产后不就的母体循环中所发现的胎儿红细胞的数量在许多情况下都很小，临床意义不明确，大量出血可能是由多种原因引起的，包括胎儿或母体创伤和胎盘缺陷。

含有胎血红蛋白的红细胞可能存在于任何年龄的个体中，但与胎儿红细胞相比，其中胎儿血红蛋白的含量较低。这些细胞被称为 F 细胞。高水平 F 细胞也可能存在于具有不确定病因的异质遗传疾病组的成人中，称为胎儿血红蛋白的遗传性持久性。其他导致严重贫血的临床疾病也可能导致 F 细胞水平升高。F 细胞水平升高时，描述了几种临床疾病。这些疾病包括遗传性贫血病（如镰状细胞贫血症和重型地中海贫血症）。

相关链接
使用 Spectraviewer 可帮助规划实验。还提供有关赛默飞世尔科技流式细胞分析产品和支持的其他一般信息。

仅供科研使用。不可用于诊断程序。

抗体偶联物传统染料（例如 FITC、TRITC），FITC（荧光素）

检测方法荧光

适用于（应用）流式细胞分析抗体与二次检测

产品规格试剂盒

标签或染料FITC（荧光素）

数量100 次测试

运输条件湿冰

类型血红蛋白检测试剂盒

CE 标志是

Unit SizeEach

内容与储存

储存在冰箱 (2–8°C) 中。

引用和文献 (6)

引用和文献

Abstract

Detection of fetomaternal hemorrhage.

Authors:Kim YA, Makar RS,

Journal:Am J Hematol

PubMed ID:22231030

'The prevention of Rhesus D alloimmunization through Rh immune globulin (RhIg) administration is the major indication for the accurate detection and quantification of fetomaternal hemorrhage (FMH). In the setting of D incompatibility, D-positive fetal cells can sensitize the D-negative mother, resulting in maternal anti-D alloantibody production. These anti-D alloantibodies may ... More

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease.

Authors:Zou J, Mali P, Huang X, Dowey SN, Cheng L,

Journal:Blood

PubMed ID:21881051

'Human induced pluripotent stem cells (iPSCs) bearing monogenic mutations have great potential for modeling disease phenotypes, screening candidate drugs, and cell replacement therapy provided the underlying disease-causing mutation can be corrected. Here, we report a homologous recombination-based approach to precisely correct the sickle cell disease (SCD) mutation in patient-derived iPSCs ... More

Improving laboratory practice: looking at fetal hemoglobin histograms.

Authors:Warzynski MJ, Roys JL,

Journal:Cytometry B Clin Cytom

PubMed ID:14994377

Estimation of

Authors:Roys JL, Warzynski MJ,

Journal:Cytometry B Clin Cytom

PubMed ID:16059876

Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen-mismatched RBCs.

Authors:Widness JA, Nalbant D, Matthews NI, Strauss RG, Schmidt RL, Cress GA, Zimmerman MB, Mock DM,

Journal:

PubMed ID:24108188

Anemia, a common condition among critically ill premature infants, is affected by red blood cell (RBC) survival (RCS). We hypothesized that transfused allogeneic Kidd antigen-mismatched RBCs would demonstrate the same concurrent RCS tracking as RBCs multilabeled at separate, discrete low densities with biotin (BioRBCs). Allogeneic RBCs from adult donors were ... More

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