Multicopy blaOXA-58 gene as a source of high-level resistance to carbapenems in Acinetobacter baumannii.
AuthorsBertini A, Poirel L, Bernabeu S, Fortini D, Villa L, Nordmann P, Carattoli A,
JournalAntimicrob Agents Chemother
PubMed ID17438042
'The mechanisms at the origin of heterogeneous carbapenem resistance levels observed among Acinetobacter baumannii isolates collected in 2005 in a large University Hospital of Rome, Italy, were investigated. These isolates were related and possessed similar plasmids carrying the carbapenem-hydrolyzing oxacillinase gene bla(OXA-58) but showed variable levels of resistance to carbapenems. ... More
Role of LRAT on the retinoid isomerase activity and membrane association of Rpe65.
AuthorsJin M, Yuan Q, Li S, Travis GH,
JournalJ Biol Chem
PubMed ID17504753
Absorption of a photon by a vertebrate opsin pigment induces 11-cis to all-trans isomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the bleached opsin requires chemical re-isomerization of the chromophore via an enzyme pathway called the visual cycle. The retinoid isomerase in this pathway is Rpe65, a membrane-associated ... More