Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii.
AuthorsHéritier C, Poirel L, Lambert T, Nordmann P
JournalAntimicrob Agents Chemother
PubMed ID16048925
'Carbapenem-hydrolyzing oxacillinases are reported increasingly in Acinetobacter baumannii. Since they hydrolyze carbapenems at low levels, the roles of carbapenem-hydrolyzing oxacillinases OXA-23, OXA-40, and OXA-58 in A. baumannii were determined. The bla(OXA-23), bla(OXA-40), and bla(OXA-58) genes were inserted in broad-host-range plasmid pAT801 and transformed in Escherichia coli DH10B and in A. ... More
A gene network for long-day flowering activates RFT1 encoding a mobile flowering signal in rice.
AuthorsKomiya R, Yokoi S, Shimamoto K
JournalDevelopment
PubMed ID19762423
'Although some genes that encode sensory or regulatory elements for photoperiodic flowering are conserved between the long-day (LD) plant Arabidopsis thaliana and the short-day (SD) plant rice, the gene networks that control rice flowering, and particularly flowering under LD conditions, are not well understood. We show here that RICE FLOWERING ... More
Estrogen receptor-mediated regulation of microRNA inhibits proliferation of vascular smooth muscle cells.
AuthorsZhao J, Imbrie GA, Baur WE, Iyer LK, Aronovitz MJ, Kershaw TB, Haselmann GM, Lu Q, Karas RH
JournalArterioscler Thromb Vasc Biol
PubMed ID23175673
Estradiol (E2) regulates gene transcription by activating estrogen receptor-a and estrogen receptor-ß. Many of the genes regulated by E2 via estrogen receptors are repressed, yet the molecular mechanisms that mediate E2-induced gene repression are currently unknown. We hypothesized that E2, acting through estrogen receptors, regulates expression of microRNAs (miRs) leading ... More
Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressor.
AuthorsBailey JR, O'Connell K, Yang HC, Han Y, Xu J, Jilek B, Williams TM, Ray SC, Siliciano RF, Blankson JN
JournalJ Virol
PubMed ID18495769
Elite suppressors (ES) are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain viral loads of <50 copies/ml. The mechanisms involved in this control of viral replication remain unclear. Prior studies suggested that these patients, as well as long-term nonprogressors, are infected with defective HIV-1 variants. Other reports have ... More