Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells.
AuthorsBehrend L, Mohr A, Dick T, Zwacka RM,
JournalMol Cell Biol
PubMed ID16107721
The mitochondrial enzyme manganese superoxide dismutase (MnSOD) is known to suppress cell growth in different tumor cell lines. However, the molecular mechanism of this growth-retarding effect is not fully understood. Here we show that overexpression of MnSOD slows down growth of HCT116 human colorectal cancer cells by induction of cellular ... More