Positional cloning of the murine flavivirus resistance gene.
Authors Perelygin Andrey A; Scherbik Svetlana V; Zhulin Igor B; Stockman Bronislava M; Li Yan; Brinton Margo A;
JournalProc Natl Acad Sci U S A
PubMed ID12080145
'Inbred mouse strains exhibit significant differences in their susceptibility to viruses in the genus Flavivirus, which includes human pathogens such as yellow fever, Dengue, and West Nile virus. A single gene, designated Flv, confers this differential susceptibility and was mapped previously to a region of mouse chromosome 5. A positional ... More
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
AuthorsOzinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A
JournalProc Natl Acad Sci U S A
PubMed ID11095740
Toll-like receptors (TLRs) have been shown to participate in the recognition of pathogens by the innate immune system, but it is not clear how a restricted family of receptors has the capacity to recognize the wide spectrum of TLR stimuli known to exist. We report here that two members of ... More
CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling.
Authors Yu Wei-Hsuan; Woessner J Frederick Jr; McNeish John D; Stamenkovic Ivan;
JournalGenes Dev
PubMed ID11825873
CD44 is a facultative proteoglycan implicated in cell adhesion and trafficking, as well as in tumor survival and progression. We demonstrate here that CD44 heparan sulfate proteoglycan (CD44HSPG) recruits proteolytically active matrix metalloproteinase 7 (matrilysin, MMP-7) and heparin-binding epidermal growth factor precursor (pro-HB-EGF) to form a complex on the surface ... More
Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.
Authors Lee Hahn-Jun; Jung Kwang-Mook; Huang Yang Z; Bennett Lori B; Lee Joanne S; Mei Lin; Kim Tae-Wan;
JournalJ Biol Chem
PubMed ID11741961
An unusual protease gamma-secretase requires functional presenilins and cleaves substrates (e.g. amyloid beta-protein precursor and Notch) with very loose amino acid sequence specificity within the transmembrane region. Here we report that ErbB4, a tyrosine kinase receptor for neuregulins, is a substrate for presenilin-dependent gamma-secretase. Our studies show that constitutive ectodomain ... More