WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition.
AuthorsHo H, Kapadia R, Al-Tahan S, Ahmad S, Ganesan AK,
JournalJ Biol Chem
PubMed ID21317285
'Recent studies implicate a role for WD repeat domain, phosphoinositide-interacting 1 (WIPI1) in the biogenesis of melanosomes, cell type-specific lysosome-related organelles. In this study, we determined that WIPI1, an ATG18 homologue that is shown to localize to both autophagosomes and early endosomes, inhibited mammalian target of rapamycin (MTOR) signaling, leading ... More
AuthorsDelpeut S, Rudd PA, Labonté P, von Messling V,
JournalJ Virol
PubMed ID22647692
In the context of viral infections, autophagy induction can be beneficial or inhibitory. Within the Paramyxoviridae family, only morbilliviruses have been investigated and are reported to induce autophagy. Here we show that morbilliviruses rapidly induce autophagy and require this induction for efficient cell-to-cell spread. Coexpression of both glycoproteins in cells ... More
Hormonally active vitamin D3 (1alpha,25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection.
AuthorsCampbell GR, Spector SA,
JournalJ Biol Chem
PubMed ID21454634
Autophagy is a self-digestion pathway essential for maintaining cellular homeostasis and cell survival and for degrading intracellular pathogens. Human immunodeficiency virus-1 (HIV-1) may utilize autophagy for replication as the autophagy-related protein-7 (ATG-7), microtubule-associated protein 1 light chain 3, ATG-12, and ATG-16L2 are required for productive HIV-1 infection; however, the effects ... More
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
Authors
JournalMBio
PubMed ID34225486
Malpighian Tubule Cells in Overwintering Cave Crickets Troglophilus cavicola (Kollar, 1833) and T. neglectus Krauss, 1879 (Rhaphidophoridae, Ensifera).
AuthorsLipovšek S, Novak T, Janžekovic F, Weiland N, Leitinger G
JournalPLoS One
PubMed ID27379687
'During winter, cave cricket larvae undergo dormancy in subterranean habitats; this dormancy is termed diapause in second year Troglophilus cavicola larvae because they mature during this time, and termed quiescence in T. neglectus, because they mature after dormancy. Here we used electron microscopy to analyze ultrastructural changes in the epithelial ... More
Oxysterols in adipose tissue-derived mesenchymal stem cell proliferation and death.
AuthorsSilva SF, Levy D, Ruiz JLM, de Melo TC, Isaac C, Fidelis ML, Rodrigues A, Bydlowski SP
JournalJ Steroid Biochem Mol Biol
PubMed ID27133385
'Mesenchymal stem cells (MSCs) are multipotent cells characterized by self-renewal and cellular differentiation capabilities. Oxysterols comprise a very heterogeneous group derived from cholesterol through enzymatic and non-enzymatic oxidation. Potent effects in cell death processes, including cytoxicity and apoptosis induction, were described in several cell lines. Very little is known about ... More
High content screen for identifying small-molecule LC3B-localization modulators in a renal cancer cell line.
'Forms of selective autophagy have now been recognized to regulate flux in many intracellular processes. Specific pathways and functions have been identified for mitophagy, ERphagy, and other selective autophagies; yet there is no consensus in whether and how autophagy regulates protein maintenance in and around the nucleus. Such processes are ... More
WX20120108, a novel IAP antagonist, induces tumor cell autophagy via activating ROS-FOXO pathway.
AuthorsDing R, Wang X, Chen W, Li Z, Wei AL, Wang QB, Nie AH, Wang LL
JournalActa Pharmacol Sin
PubMed ID31316176
'Recently, inhibitor of apoptosis proteins (IAPs) and some IAP antagonists were found to regulate autophagy, but the underlying mechanisms remain unclear. WX20120108 is an analogue of GDC-0152 (a known IAP antagonist) and displays more potent anti-tumor and autophagy-regulating activity in tumor cells, we investigated the regulatory mechanisms underlying WX20120108-induced autophagy. ... More
Zika virus depletes neural stem cells and evades selective autophagy by suppressing the Fanconi anemia protein FANCC.
Authors
JournalEMBO Rep
PubMed ID33073500
The ubiquitin ligase parkin mediates resistance to intracellular pathogens.
Authors
JournalNature
PubMed ID24005326
Oxidative stress impairs autophagic flux in prion protein-deficient hippocampal cells.
Authors
JournalAutophagy
PubMed ID22889724
Inhibition of Autophagy Does Not Re-Sensitize Acute Myeloid Leukemia Cells Resistant to Cytarabine.
Authors
JournalInt J Mol Sci
PubMed ID33652766
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity.
Authors
JournalFront Immunol
PubMed ID33240287
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.
Authors
JournalNat Cell Biol
PubMed ID23604317
A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy.
Authors
JournalNat Cell Biol
PubMed ID26098573
The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.
Authors
JournalAutophagy
PubMed ID26086204
Autophagic myelin destruction by Schwann cells during Wallerian degeneration and segmental demyelination.
AuthorsJang SY, Shin YK, Park SY, Park JY, Lee HJ, Yoo YH, Kim JK, Park HT
JournalGlia
PubMed ID26712109
As lysosomal hydrolysis has long been suggested to be responsible for myelin clearance after peripheral nerve injury, in this study, we investigated the possible role of autophagolysosome formation in myelin phagocytosis by Schwann cells and its final contribution to nerve regeneration. We found that the canonical formation of autophagolysosomes was ... More
Exposure to BDE-153 induces autophagy in HepG2 cells.
Autophagy is a pro-survival process that occurs under stressful "life-threatening" conditions. This process clears the cells of damaged organelles, long-lived proteins, and/or misfolded proteins. Under stressful conditions, activation of the autophagic process leads to cell death and acts as a protective mechanism against xenobiotic, which is the most widely accepted ... More
TRIM14 Is a Key Regulator of the Type I IFN Response during
AuthorsHoffpauir CT, Bell SL, West KO, Jing T, Wagner AR, Torres-Odio S, Cox JS, West AP, Li P, Patrick KL, Watson RO
JournalJ Immunol
PubMed ID32404352
Tripartite motif-containing proteins (TRIMs) play a variety of recently described roles in innate immunity. Although many TRIMs regulate type I IFN expression following cytosolic nucleic acid sensing of viruses, their contribution to innate immune signaling and gene expression during bacterial infection remains largely unknown. Because ... More