Localization of sphingosine kinase-1 in mouse sperm acrosomes.
Authors:Matsumoto K, Banno Y, Murate T, Akao Y, Nozawa Y
Journal:J Histochem Cytochem
PubMed ID:15684337
Sphingosine kinase (SPHK) catalyzes sphingosine phosphorylation to form a bioactive lipid mediator, sphingosine-1-phosphate (S1P). In the current study, we report the presence of SPHK-1 in mouse spermatozoa. SPHK-1 was localized to the acrosomes of spermatozoa, and its expression was proven by RT-PCR and Western blot analysis. SPHK activity of mouse ... More