Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.
Authors:Kumar RA, Koc A, Cerny RL, Gladyshev VN,
Journal:J Biol Chem
PubMed ID:12145281
Methionine residues in proteins are susceptible to oxidation, and the resulting methionine sulfoxides can be reduced back to methionines by methionine-S-sulfoxide reductase (MsrA) and methionine-R-sulfoxide reductase (MsrB). Herein, we have identified two MsrB families that differ by the presence of zinc. Evolutionary analyses suggested that the zinc-containing MsrB proteins are ... More
The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes.
Authors: Yin Yong; Edelman Gerald M; Vanderklish Peter W;
Journal:Proc Natl Acad Sci U S A
PubMed ID:11842217
Protein synthesis in neurons is essential for the consolidation of memory and for the stabilization of activity-dependent forms of synaptic plasticity such as long-term potentiation (LTP). Activity-dependent translation of dendritically localized mRNAs has been proposed to be a critical source of new proteins necessary for synaptic change. mRNA for the ... More
CREB-binding protein/p300 co-activation of crystallin gene expression.
Authors: Chen Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A;
Journal:J Biol Chem
PubMed ID:11943779
Although some of the transcription factors that are required for expression of crystallins during lens development have been identified, the molecular interactions that contribute to enhanced crystallin expression are not yet well defined. In this study, we designed experiments to test whether the co-activators CREB-binding protein (CBP) and/or p300 interact ... More
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.
Authors: Dahlgren Karie N; Manelli Arlene M; Stine W Blaine Jr; Baker Lorinda K; Krafft Grant A; LaDu Mary Jo;
Journal:J Biol Chem
PubMed ID:12058030
Genetic evidence predicts a causative role for amyloid-beta (A beta) in Alzheimer's disease. Recent debate has focused on whether fibrils (amyloid) or soluble oligomers of A beta are the active species that contribute to neurodegeneration and dementia. We developed two aggregation protocols for the consistent production of stable oligomeric or ... More