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Invitrogen
CGRP Monoclonal Antibody (4901)
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Product Details
MA1-20209
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4901
Immunogen
Rat alpha-CGRP peptide. The epitope recognized by the antibody resides within the C-terminal ten amino acids of rat alpha-CGRP.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.1 mg/mL
Amount
105 µg
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: rat alpha-CGRP.
MA1-20209 has been successfully used in ELISA, radioimmune assay, neutralizing, and immunocytochemistry procedures.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-CGRP; alpha-type calcitonin gene-related peptide; alpha-type CGRP; calcitonin; calcitonin 1; calcitonin gene related protein; calcitonin gene-related peptide 1; calcitonin gene-related peptide I; calcitonin precursor; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; katacalcin; MGC126648; neuropeptide; alpha-CGRP; prepro-alpha-calcitonin gene-related peptide; procalcitonin; RAT calcitonin; unnamed protein product
Gene Aliases: CA; Cal1; CAL6; CALC; CALC1; calcitonin; CCALCI; CGRP; CGRP-1; CGRP-alpha; CGRP-I; CGRP1; CT; Ctn; KC; PCT; RATCAL6
UniProt ID: (Dog) P41547, (Human) P01258, (Mouse) P70160, (Rat) P01256
Entrez Gene ID: (Dog) 403946, (Human) 796, (Mouse) 12310, (Rat) 24241
signal transduction
response to yeast
endothelial cell proliferation
vasculature development
neurological system process involved in regulation of systemic arterial blood pressure
G-protein coupled receptor internalization
monocyte chemotaxis
protein phosphorylation
leukocyte cell-cell adhesion
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
embryo implantation
regulation of blood pressure
negative regulation of calcium ion transport into cytosol
antibacterial humoral response
antifungal humoral response
receptor internalization
activation of protein kinase activity
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-8 production
vasodilation
endothelial cell migration
innate immune response
positive regulation of macrophage differentiation
negative regulation of osteoclast differentiation
negative regulation of blood pressure
negative regulation of bone resorption
negative regulation of transcription, DNA-templated
negative regulation of smooth muscle contraction
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
regulation of cytosolic calcium ion concentration
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to tumor necrosis factor
calcitonin family receptor signaling pathway
amylin receptor 1 signaling pathway
amylin receptor 2 signaling pathway
cellular response to nerve growth factor stimulus
calcitonin gene-related peptide receptor signaling pathway
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
regulation of heart rate
cellular calcium ion homeostasis
inflammatory response
neuropeptide signaling pathway
feeding behavior
response to heat
negative regulation of ossification
negative regulation of neurological system process
positive regulation of ossification
sperm capacitation
response to pain
detection of temperature stimulus involved in sensory perception of pain
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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