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Invitrogen
Phospho-PERK (Thr980) Monoclonal Antibody (G.305.4)
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Phospho-PERK (Thr980) Antibody (MA5-15033) in WB
Western blot was performed using anti-Phospho-PERK (Thr980) Monoclonal Antibody (G.305.4) (Product # MA5-15033) and a 125 kDa band corresponding to Phospho-PERK was induced in RSC96 cells upon thapsigargin and tunicamycin treatments which are known to induce ER stress. Whole cell extracts (30 µg lysate) of RSC96 (Lane1), RSC96 treated with Thapsigargin (300nM for 2hrs) (Lane 2) and RSC96 with Tunicamycin (4... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-15033
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
G.305.4
抗原
Synthetic phosphopeptide corresponding to residues surrounding pThr980 of mouse PERK
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
441 µg/mL
规格
44.1 µg
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
<0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 3; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; Protein tyrosine kinase EIF2AK3
基因别名: Eif2ak3; PEK; Perk
UniProt ID: (Rat) Q9Z1Z1
Entrez Gene ID: (Rat) 29702
skeletal system development
ossification
angiogenesis
chondrocyte development
translation
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
ER overload response
endoplasmic reticulum organization
lactation
positive regulation of signal transduction
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of gene expression
regulation of translational initiation by eIF2 alpha phosphorylation
negative regulation of translation
regulation of fatty acid metabolic process
calcium-mediated signaling
bone mineralization
endoplasmic reticulum unfolded protein response
pancreas development
endocrine pancreas development
negative regulation of myelination
negative regulation of translation in response to stress
negative regulation of translational initiation in response to stress
positive regulation of protein binding
SREBP signaling pathway
response to endoplasmic reticulum stress
cellular response to glucose starvation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of transcription from RNA polymerase I promoter
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
protein homooligomerization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
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