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Invitrogen
UBC13 Recombinant Rabbit Monoclonal Antibody (10O9Z5)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-35787
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
10O9Z5
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Ube2N/Ubc13 (P61088)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.93 mg/mL
规格
93 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAGLPRRIIK ETQRLLAEPV PGIKAEPDES NARYFHVVIA GPQDSPFEGG TFKLELFLPE EYPMAAPKVR FMTKIYHPNV DKLGRICLDI LKDKWSPALQ
靶标信息
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production. UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. (Uniprot)
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bendless protein; Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; MGC131857; MGC8489; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); Ubiquitin-protein ligase N
基因别名: 1500026J17Rik; AL022654; BB101821; BLU; UBC13; UBE2N
UniProt ID: (Rat) Q9EQX9, (Mouse) P61089
Entrez Gene ID: (Rat) 116725, (Mouse) 93765
ubiquitin-protein transferase activity
ATP binding
ligase activity
ubiquitin-like protein transferase activity
ubiquitin protein ligase binding
ubiquitin binding
poly(A) RNA binding
ubiquitin protein ligase activity
ubiquitin conjugating enzyme activity
nucleotide binding
protein binding
ubiquitin-protein ligase
double-strand break repair via homologous recombination
DNA double-strand break processing
postreplication repair
ubiquitin-dependent protein catabolic process
protein ubiquitination
histone ubiquitination
positive regulation of histone modification
regulation of histone ubiquitination
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of DNA repair
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
positive regulation of ubiquitin-protein transferase activity
protein K63-linked ubiquitination
DNA repair
cellular response to DNA damage stimulus
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