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Invitrogen
IST1 Polyclonal Antibody
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FIGURE: 1 / 2
IST1 Antibody (PA5-106294) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded IST1 in mouse spleen tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with IST1 polyclonal antibody (Product # PA5-106294) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106294
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IST1(Accession P53990), corresponding to amino acid residues P246-Q296.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total IST1.
Target Information
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charged multivesicular body protein 8; CHMP8; hIST1; IST1 homolog; MGC117220; pm28; Putative MAPK-activating protein PM28
Gene Aliases: 2400003C14Rik; AW536298; IST1; KIAA0174; mKIAA0174
UniProt ID: (Mouse) Q9CX00
Entrez Gene ID: (Mouse) 71955
cytokinesis
positive regulation of defense response to virus by host
cell cycle
protein localization
abscission
viral release from host cell
establishment of protein localization
positive regulation of proteolysis
viral capsid secondary envelopment
positive regulation of collateral sprouting
cell division
mitophagy in response to mitochondrial depolarization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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