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Invitrogen
CGRP Polyclonal Antibody
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图: 1 / 5
CGRP Antibody (PA5-114929) in ICC/IF
Immunocytochemistry analysis of CGRP in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114929) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-114929
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CALCA(Accession P06881), corresponding to amino acid residues G96-S116.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CALCA.
靶标信息
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha-type CGRP; Calcitonin; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; MGC126648; RAT calcitonin
基因别名: CA; Cal1; CAL6; Calc; CALC1; CALCA; calcitonin; CGRP; CGRP-1; CGRP1; Ct; Ctn; RATCAL6
UniProt ID: (Rat) P01256, (Mouse) Q99JA0
Entrez Gene ID: (Rat) 24241, (Mouse) 12310
endothelial cell proliferation
vasculature development
neurological system process involved in regulation of systemic arterial blood pressure
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
regulation of heart rate
G-protein coupled receptor internalization
monocyte chemotaxis
protein phosphorylation
cellular calcium ion homeostasis
inflammatory response
leukocyte cell-cell adhesion
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
neuromuscular junction development
embryo implantation
aging
feeding behavior
regulation of heart contraction
regulation of blood pressure
response to heat
negative regulation of calcium ion transport into cytosol
negative regulation of ossification
positive regulation of cAMP biosynthetic process
receptor internalization
negative regulation of neurological system process
activation of protein kinase activity
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-8 production
vasodilation
endothelial cell migration
positive regulation of macrophage differentiation
negative regulation of osteoclast differentiation
positive regulation of adenylate cyclase activity
negative regulation of blood pressure
positive regulation of ossification
negative regulation of bone resorption
positive regulation of cell adhesion
negative regulation of transcription, DNA-templated
positive regulation of vasodilation
negative regulation of smooth muscle contraction
response to pain
detection of temperature stimulus involved in sensory perception of pain
regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
cellular response to tumor necrosis factor
cellular response to nerve growth factor stimulus
sperm capacitation
mitophagy in response to mitochondrial depolarization
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