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Invitrogen
DMRT1 Polyclonal Antibody
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DMRT1 Antibody (PA5-79160) in IHC (P)
Immunohistochemical analysis of DMRT1 in paraffin-embedded section of mouse testis tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-DMRT1 antibody (Product # PA5-79160) overnight at 4°C. Biotinylated goat anti-rabbit IgG was u... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79160
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human DMRT1 (98-128aa RDCQCKKCNLIAERQRVMAAQVALRRQQAQE).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat testis tissue, mouse testis tissue. IHC: mouse testis tissue, rat testis tissue, human testis tissue.
靶标信息
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DM domain expressed in testis protein 1; Doublesex- and mab-3-related transcription factor 1
基因别名: DMRT1; DMT1
UniProt ID: (Mouse) Q9QZ59
Entrez Gene ID: (Mouse) 50796, (Rat) 114498
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
protein heterodimerization activity
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
male germ cell proliferation
developmental process involved in reproduction
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
spermatogenesis
sex differentiation
germ cell migration
male gonad development
cell differentiation
male sex determination
intracellular signal transduction
negative regulation of meiotic nuclear division
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
male sex differentiation
oocyte development
Sertoli cell differentiation
Sertoli cell development
positive regulation of meiosis I
regulation of nodal signaling pathway
positive regulation of male gonad development
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