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Invitrogen
ITPA Polyclonal Antibody
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ITPA Antibody (PA5-88421) in WB
Western blot analysis of ITPA in extracts of various cell lines. Samples were incubated with ITPA Polyclonal antibody (Product # PA5-88421) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-88421
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human ITPA (NP_2584121)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.58 mg/mL
规格
58 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MAASLVGKKI VFVTGNAKKL EEVVQILGDK FPCTLVAQKI DLPEYQGEPD EISIQKCQEA VRQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLAGFEDK SAYALCTFAL STGDPSQPVR LFRGRTSGRI VAPRGCQDFG WDPCFQPDGY EQTYAEMPKA EKNAVSHRFR ALLELQEYFG SLAA; Positive Samples: U-87MG, HT-29, Mouse small intestine, Mouse heart, Rat liver; Cellular Location: Cytoplasm
靶标信息
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; ITPase; ITPase {ECO:0000255|HAMAP-Rule:MF_03148}; My049 protein; Non-canonical purine NTP pyrophosphatase; non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Non-standard purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; NTPase; NTPase {ECO:0000255|HAMAP-Rule:MF_03148}; nucleoside triphosphate pyrophosphatase; Nucleoside-triphosphate diphosphatase; nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Nucleoside-triphosphate pyrophosphatase; nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; XTP/dITP diphosphatase
基因别名: 2010016I08Rik; AU020102; Itp; Itpa
UniProt ID: (Rat) D3ZW55, (Mouse) Q9D892
Entrez Gene ID: (Rat) 311422, (Mouse) 16434
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