Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics.
Authors:Zhu G, Zheng J, Song E, Donovan M, Zhang K, Liu C, Tan W,
Journal:Proc Natl Acad Sci U S A
PubMed ID:23630258
'Nanotechnology has allowed the construction of various nanostructures for applications, including biomedicine. However, a simple target-specific, economical, and biocompatible drug delivery platform with high maximum tolerated doses is still in demand. Here, we report aptamer-tethered DNA nanotrains (aptNTrs) as carriers for targeted drug transport in cancer therapy. Long aptNTrs were ... More