aVß3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts.
Authors:Gianni T, Campadelli-Fiume G,
Journal:J Virol
PubMed ID:22171266
'Herpes simplex virus (HSV) enters cells by fusion at plasma membranes or endosomes. Cellular factors route the virus to different pathways. aVß3-integrin directs HSV to a lipid raft and acidic endosome pathway. We report that infection mediated by nectin1 plus aVß3-integrin exhibits the same characteristics as entry mediated by raft-located ... More
Looking at lipid rafts?
Authors:Jacobson K, Dietrich C
Journal:Trends Cell Biol
PubMed ID:10201072
'The notion that microdomains enriched in certain specialized lipids exist in membranes has been both attractive and controversial since it was first proposed that such domains, termed rafts, might act as apical sorting devices in epithelial cells. The observation that certain lipids are not extractable in cold nonionic detergent supports ... More
Functions of lipid rafts in biological membranes.
Authors:Brown DA, London E
Journal:Annu Rev Cell Dev Biol
PubMed ID:9891780
'Recent studies showing that detergent-resistant membrane fragments can be isolated from cells suggest that biological membranes are not always in a liquid-crystalline phase. Instead, sphingolipid and cholesterol-rich membranes such as plasma membranes appear to exist, at least partially, in the liquid-ordered phase or a phase with similar properties. Sphingolipid and ... More
Lipid rafts make for slippery platforms.
Authors:Lai EC
Journal:J Cell Biol
PubMed ID:12885764
What's in a raft? Although cell membranes are certainly not homogeneous mixtures of lipids and proteins, almost all aspects of lipid rafts-how to define them, their size, composition, lifetime, and biological relevance-remain controversial. The answers will shape our views of signaling and of membrane dynamics. ... More
Lipid rafts and little caves. Compartmentalized signalling in membrane microdomains.
Authors:Zajchowski LD, Robbins SM
Journal:Eur J Biochem
PubMed ID:11846775
Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane of most, if not all, mammalian cells. A large number of signalling molecules are concentrated within rafts, which have been proposed to function as signalling centres capable of facilitating efficient and specific ... More