aVß3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts.
AuthorsGianni T, Campadelli-Fiume G,
JournalJ Virol
PubMed ID22171266
'Herpes simplex virus (HSV) enters cells by fusion at plasma membranes or endosomes. Cellular factors route the virus to different pathways. aVß3-integrin directs HSV to a lipid raft and acidic endosome pathway. We report that infection mediated by nectin1 plus aVß3-integrin exhibits the same characteristics as entry mediated by raft-located ... More
Looking at lipid rafts?
AuthorsJacobson K, Dietrich C
JournalTrends Cell Biol
PubMed ID10201072
'The notion that microdomains enriched in certain specialized lipids exist in membranes has been both attractive and controversial since it was first proposed that such domains, termed rafts, might act as apical sorting devices in epithelial cells. The observation that certain lipids are not extractable in cold nonionic detergent supports ... More
Functions of lipid rafts in biological membranes.
AuthorsBrown DA, London E
JournalAnnu Rev Cell Dev Biol
PubMed ID9891780
'Recent studies showing that detergent-resistant membrane fragments can be isolated from cells suggest that biological membranes are not always in a liquid-crystalline phase. Instead, sphingolipid and cholesterol-rich membranes such as plasma membranes appear to exist, at least partially, in the liquid-ordered phase or a phase with similar properties. Sphingolipid and ... More
Lipid rafts make for slippery platforms.
AuthorsLai EC
JournalJ Cell Biol
PubMed ID12885764
What's in a raft? Although cell membranes are certainly not homogeneous mixtures of lipids and proteins, almost all aspects of lipid rafts-how to define them, their size, composition, lifetime, and biological relevance-remain controversial. The answers will shape our views of signaling and of membrane dynamics. ... More
Lipid rafts and little caves. Compartmentalized signalling in membrane microdomains.
AuthorsZajchowski LD, Robbins SM
JournalEur J Biochem
PubMed ID11846775
Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane of most, if not all, mammalian cells. A large number of signalling molecules are concentrated within rafts, which have been proposed to function as signalling centres capable of facilitating efficient and specific ... More
MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse.
AuthorsHiltbold EM, Poloso NJ, Roche PA
JournalJ Immunol
PubMed ID12538693
Activation of CD4(+) Th cells requires their cognate interaction with APCs bearing specific relevant MHC class II-peptide complexes. This cognate interaction culminates in the formation of an immunological synapse that contains the various proteins and lipids required for efficient T cell activation. We now show that APC lipid raft membrane ... More
Lipid rafts: bringing order to chaos.
AuthorsPike LJ
JournalJ Lipid Res
PubMed ID12562849
Lipid rafts are subdomains of the plasma membrane that contain high concentrations of cholesterol and glycosphingolipids. They exist as distinct liquid-ordered regions of the membrane that are resistant to extraction with nonionic detergents. Rafts appear to be small in size, but may constitute a relatively large fraction of the plasma ... More
Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).
AuthorsHooper NM
JournalMol Membr Biol
PubMed ID10417979
Within the cell membrane glycosphingolipids and cholesterol cluster together in distinct domains or lipid rafts, along with glycosyl-phosphatidylinositol (GPI)-anchored proteins in the outer leaflet and acylated proteins in the inner leaflet of the bilayer. These lipid rafts are characterized by insolubility in detergents such as Triton X-100 at 4 degrees ... More
Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization.
Authors
JournalElife
PubMed ID34342264
Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma.
Authors
JournalMol Cancer Res
PubMed ID33288734
Patching of ganglioside(M1) in human erythrocytes - distribution of CD47 and CD59 in patched and curved membrane.
Authors
JournalMol Membr Biol
PubMed ID18428041
Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5.
Authors
JournalJ Comp Neurol
PubMed ID22120520
Membrane Cholesterol Is a Critical Determinant for Hippocampal Neuronal Polarity.
Authors
JournalFront Mol Neurosci
PubMed ID34744625
Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle.
Authors
JournalJ Clin Invest
PubMed ID33591957
ELOVL5-Mediated Long Chain Fatty Acid Elongation Contributes to Enzalutamide Resistance of Prostate Cancer.
Authors
JournalCancers (Basel)
PubMed ID34439125
S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse.
Authors
JournalElife
PubMed ID34913437
Enhanced enzymatic production of cholesteryl 6'-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori.