Novel designs of multivalent anti-CD20 humanized antibodies as improved lymphoma therapeutics.
AuthorsRossi EA, Goldenberg DM, Cardillo TM, Stein R, Wang Y, Chang CH,
JournalCancer Res
PubMed ID18922911
'Multivalent antibodies, either monospecific or bispecific, may improve the efficacy of current therapeutic interventions involving a single monoclonal antibody (mAb). We have applied the Dock-and-Lock (DNL) method, a new platform technology for the site-specific and covalent assembly of modular components into stably tethered complexes of defined composition, to prepare a ... More
A general process for the development of peptide-based immunoassays for monoclonal antibodies.
'PURPOSE: Monoclonal antibodies (mAb) are an important and growing class of cancer therapeutics, but pharmacokinetic analyses have in many cases been constrained by the lack of standard and robust pharmacologic assays. The goal of this project was to develop a general method for the production of immunoassays that can measure ... More