SIA（琥珀酰亚胺碘乙酸酯）
SIA（琥珀酰亚胺碘乙酸酯）
引用和文献 (2)
Thermo Scientific™

SIA（琥珀酰亚胺碘乙酸酯）

Thermo Scientific Pierce SIA is a very short (1.5 angstrom) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl了解更多信息
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货号数量
2234950 mg
货号 22349
价格（CNY)
1,272.00
飞享价
Ends: 31-Dec-2025
1,624.00
共减 352.00 (22%)
Each
添加至购物车
数量:
50 mg
请求批量或定制报价
价格（CNY)
1,272.00
飞享价
Ends: 31-Dec-2025
1,624.00
共减 352.00 (22%)
Each
添加至购物车
Thermo Scientific Pierce SIA is a very short (1.5 angstrom) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl reactive groups.

Features of SIA:

• Reactive groups: NHS ester and iodoacetyl
• Reactive toward: amino and sulfhydryl groups
• Shortest sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker available; compare to SIAB
• NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
• Iodoacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bond
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)

Product References:

Crosslinker Application Guide -- search for recent literature references for this product
仅供科研使用。不可用于诊断程序。
规格
细胞渗透性是
描述SIA
形式实心
标记方法化学标记
分子量283.02
聚乙二醇化否
产品线Pierce
数量50 mg
反应一部分卤乙酰，NHS 酯
运输条件环境
溶解度DMF、DMSO
间隔臂长1.5 Å
水溶性否
化学反应性胺-巯基
可裂解否
交联剂类型异型双功能团试剂
产品规格标准
产品类型交联剂
间隔子短 (<10 Å)
Unit SizeEach
内容与储存
接收后，在 4°C 下防潮储存。

常见问题解答 (FAQ)

Can you provide the shelf-life for SIA (succinimidyl iodoacetate)?

SIA (succinimidyl iodoacetate) is covered under our general 1-year warranty and is guaranteed to be fully functional for 12 months from the date of shipment, if stored as recommended. Please see section 8.1 of our Terms & Conditions of Sale (https://www.thermofisher.com/content/dam/LifeTech/Documents/PDFs/Terms-and-Conditions-of-Sale.pdf) for more details.

Find additional tips, troubleshooting help, and resources within our Protein Purification and Isolation Support Center.

引用和文献 (2)

引用和文献
Abstract
A central role for the T1 domain in voltage-gated potassium channel formation and function.
Authors:Strang C, Cushman SJ, DeRubeis D, Peterson D, Pfaffinger PJ
Journal:J Biol Chem
PubMed ID:11312262
To interpret the recent atomic structures of the Kv (voltage-dependent potassium) channel T1 domain in a functional context, we must understand both how the T1 domain is integrated into the full-length functional channel protein and what functional roles the T1 domain governs. The T1 domain clearly plays a role in ... More
Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical.
Authors:Chen YR, Chen CL, Chen W, Zweier JL, Augusto O, Radi R, Mason RP
Journal:J Biol Chem
PubMed ID:14761966
Oxidative alteration of mitochondrial cytochrome c (cyt c) has been linked to disease pathophysiology and is one of the causative factors for pro-apoptotic events. Hydrogen peroxide induces a short-lived cyt c-derived tyrosyl radical as detected by the electron spin resonance (ESR) spin-trapping technique. This investigation was undertaken to characterize the ... More