Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes.
Authors:Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, Vallentin A, Vial H, Vidal M, Szakacs G
Journal:PLoS One
PubMed ID:22655043
ABCB6, a member of the adenosine triphosphate-binding cassette (ABC) transporter family, has been proposed to be responsible for the mitochondrial uptake of porphyrins. Here we show that ABCB6 is a glycoprotein present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid ... More
Molecular integrity and global gene expression of breast and lung cancer stem cells under long-term storage and recovery.
Authors:Karimi-Busheri F, Zadorozhny V, Carrier E, Fakhrai H
Journal:Cell Tissue Bank
PubMed ID:22592563
'Cryopreservation is a common procedure widely used in biological and clinical sciences. Similar protocols are also applied in preserving cancer stem cells, a field with high promises and challenges. Specific cell surface membrane proteins are considered to be biomarkers of cancer stem cells and they may play a critical role ... More
CD44 is a negative cell surface marker for pluripotent stem cell identification during human fibroblast reprogramming.
Authors:Quintanilla RH, Asprer JS, Vaz C, Tanavde V, Lakshmipathy U
Journal:
PubMed ID:24416407
'Induced pluripotent stem cells (iPSCs) are promising tools for disease research and cell therapy. One of the critical steps in establishing iPSC lines is the early identification of fully reprogrammed colonies among unreprogrammed fibroblasts and partially reprogrammed intermediates. Currently, colony morphology and pluripotent stem cell surface markers are used to ... More
Enhanced dispersibility and cellular transmembrane capability of single-wall carbon nanotubes by polycyclic organic compounds as chaperon.
Authors:Wang L, Zhang L, Xue X, Ge G, Liang X
Journal:Nanoscale
PubMed ID:22628008
'The common aggregation of single-wall carbon nanotube (SWCNT) in solution is the critical obstacle to elucidate their unique physico-chemical characteristics and biological properties. Therefore, it is very important to overcome this barrier through manipulation of the weak interaction of small molecules with nanotube surface limited interface. A highly dispersed SWCNT ... More
CD86 is an activation receptor for NK cell cytotoxicity against tumor cells.
Authors:Peng Y, Luo G, Zhou J, Wang X, Hu J, Cui Y, Li XC, Tan J, Yang S, Zhan R, Yang J, He W, Wu J
Journal:
PubMed ID:24349559
'CTLA4Ig has been successfully used in the clinic for suppression of T cell activation. However, patients treated with CTLA4Ig experienced reduced incidence of tumors than predicted, but the underlying mechanism remains unknown. In this paper, we showed that brief administration of CTLA4Ig significantly reduced tumor metastasis and prolonged the survival ... More