人血浆纤维蛋白原,Alexa Fluor™ 647 偶联物
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人血浆纤维蛋白原,Alexa Fluor™ 647 偶联物
Invitrogen™

人血浆纤维蛋白原,Alexa Fluor™ 647 偶联物

Molecular Probes™ 纤维蛋白原偶联物通过将荧光染料分子连接至纯化人纤维蛋白原进行制备(每个纤维蛋白原分子连接大约 15 个染料分子),纯化偶联物以去除未反应的染料,然后冻干用于储存。荧光标记的纤维蛋白原已被证明是研究血小板活化以及随后的纤维蛋白原结合的有价值工具。例如,荧光素标记的纤维蛋白原已经用于通过流式细胞分析检测与活化的血小板结合的纤维蛋白原。人纤维蛋白原偶联物规格:•了解更多信息
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货号数量
F352005 mg
货号 F35200
价格(CNY)
3,337.00
飞享价
Ends: 31-Dec-2025
4,405.00
共减 1,068.00 (24%)
Each
添加至购物车
数量:
5 mg
价格(CNY)
3,337.00
飞享价
Ends: 31-Dec-2025
4,405.00
共减 1,068.00 (24%)
Each
添加至购物车
Molecular Probes™ 纤维蛋白原偶联物通过将荧光染料分子连接至纯化人纤维蛋白原进行制备(每个纤维蛋白原分子连接大约 15 个染料分子),纯化偶联物以去除未反应的染料,然后冻干用于储存。

荧光标记的纤维蛋白原已被证明是研究血小板活化以及随后的纤维蛋白原结合的有价值工具。例如,荧光素标记的纤维蛋白原已经用于通过流式细胞分析检测与活化的血小板结合的纤维蛋白原。

人纤维蛋白原偶联物规格:
• 标记(激发/发射波长):Alexa Fluor™ 647(约 650/668 nm)
•光谱与 Cy™5 染料偶联物相似
•冻干产品在缓冲液(例如 pH 值为 8.3 的碳酸氢钠)中溶解后使用
•通常使用荧光显微镜或流式细胞分析检测荧光


查找更多有关细胞粘附和受体结合的探针
请参阅《Molecular Probes™ 手册》中的用于细胞粘附、趋化作用、多药耐药性和谷胱甘肽的探针—第 15.6 节以及用于追踪受体结合和吞噬作用的探针—第 16.1 节,以获取有关这些探针的更多信息。

仅供研究使用。不可用于人或动物的治疗或诊断。
仅供科研使用。不可用于人或动物的治疗或诊断。
规格
标签类型Alexa Fluor 染料
产品线Alexa Fluor
蛋白质子类型纤维蛋白原
数量5 mg
运输条件室温
偶联物Alexa Fluor 647
形式Lyophilized
种属Human
Unit SizeEach
内容与储存
储存在冰箱(-5 至 -30°C)中并避光。

引用和文献 (14)

引用和文献
Abstract
Control of integrin alphaIIb beta3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates.
Authors:Podolnikova NP, Yermolenko IS, Fuhrmann A, Lishko VK, Magonov S, Bowen B, Enderlein J, Podolnikov AV, Ros R, Ugarova TP,
Journal:Biochemistry
PubMed ID:19929007
The physical properties of substrates are known to control cell adhesion via integrin-mediated signaling. Fibrin and fibrinogen, the principal components of hemostatic and pathological thrombi, may represent biologically relevant substrates whose variable physical properties control adhesion of leukocytes and platelets. In our previous work, we have shown that binding of ... More
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.
Authors:Weyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, Spencer E, Kraiss LW, Albertine KH, McIntyre TM, Zimmerman GA,
Journal:Blood
PubMed ID:17110454
'New activities of human platelets continue to emerge. One unexpected response is new synthesis of proteins from previously transcribed RNAs in response to activating signals. We previously reported that activated human platelets synthesize B-cell lymphoma-3 (Bcl-3) under translational control by mammalian target of rapamycin (mTOR). Characterization of the ontogeny and ... More
Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets.
Authors:Zou Z, Chen H, Schmaier AA, Hynes RO, Kahn ML,
Journal:Blood
PubMed ID:17170121
A unique aspect of integrin receptor function is the transmission of bidirectional signals. In platelets alphaIIbbeta3 integrins require
Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.
Authors:Bezman NA, Lian L, Abrams CS, Brass LF, Kahn ML, Jordan MS, Koretzky GA,
Journal:J Exp Med
PubMed ID:18663126
Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP76), an adaptor that plays a critical role in platelet activation in vitro, contains three N-terminal tyrosine residues that are essential for its function. We demonstrate that mice containing complementary tyrosine to phenylalanine mutations in Y145 (Y145F) and Y112 and Y128 ... More
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair.
Authors:
Journal:Nat Commun
PubMed ID:33883558