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          • Home
          • › Search Tool
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          • › Hs00167155_m1
          See other SERPINE1 GE Assays ›
          Gene Symbol:
          SERPINE1
          Gene Name:
          serpin family E member 1
          Gene Aliases:
          PAI, PAI-1, PAI1, PLANH1
          Chromosome Location:
          Chr.7: 101127087 - 101139266 on Build GRCh38
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          Assay ID Hs00167155_m1
          Best Coverage
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
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          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (20)

          Genomic Map

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          Assay Details

          Gene Symbol: SERPINE1
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_000602.4 NP_000593.1 2 - 3 431 82
          XM_017012260.1 XP_016867749.1 2 - 3 433 82
          GenBank mRNA AK297728.1 - 3 - 4 373 82
          AK298048.1 - 2 - 3 234 82
          AK316225.1 - 3 - 4 299 82
          BC010860.1 - 2 - 3 396 3893914 82
          CN309001.1 - 2 - 3 432 82
          M14083.1 - 1 - 2 217 82
          M16006.1 - 2 - 3 349 82
          X04429.1 - 2 - 3 400 82
          X04744.1 - 1 - 2 226 82
          X12701.1 - 2 - 3 400 82

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          More Information


          Updated Mapping Information

          This assay targets the same location as Clariom D transcript cluster(s) TC0700008582.hg.1
          This assay targets the same location as HTA transcript cluster(s) TC07000643.hg.1

          Set Membership:

          Ambion siRNA available Amplicon length between 71 and 85 Immune Tolerance Network Mammalian Gene Collection Recommended Assay Homo sapiens Human Tumor Metastasis Panel Human LDL Pathways Inventoried Human_LDL Human Tumor Metastasis Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene SERPINE1

          Panther Classification:

          Molecular Function -

          calmodulin-related protease inhibitor

          Gene Ontology Categories:

          Function(s) Process(es)

          chronological cell aging
          angiogenesis
          platelet degranulation
          circadian rhythm
          regulation of receptor activity
          negative regulation of plasminogen activation
          negative regulation of endopeptidase activity
          negative regulation of smooth muscle cell migration
          positive regulation of blood coagulation
          negative regulation of blood coagulation
          extracellular matrix organization
          negative regulation of cell migration
          positive regulation of interleukin-8 production
          negative regulation of cell adhesion mediated by integrin
          positive regulation of leukotriene production involved in inflammatory response
          fibrinolysis
          positive regulation of angiogenesis
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of receptor-mediated endocytosis
          positive regulation of inflammatory response
          defense response to Gram-negative bacterium
          negative regulation of fibrinolysis
          negative regulation of vascular wound healing
          negative regulation of wound healing
          cellular response to lipopolysaccharide
          positive regulation of monocyte chemotaxis
          negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
          negative regulation of smooth muscle cell-matrix adhesion
          negative regulation of endothelial cell apoptotic process
          protease binding
          serine-type endopeptidase inhibitor activity
          receptor binding
          protein binding

          MicroArray Probes:

          Affymetrix

          Array Name Probe IDs Targets Target Type
          Affymetrix Human Transcriptome Array 2.0 PSR07010027.hg.1 TC07000643.hg.1 HTA TC
          Affymetrix Human Transcriptome Array 2.0 PSR07010027.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR07010027.hg.1 ENST00000445463.2 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR07010027.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay PSR0700160709.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay PSR0700160709.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay PSR0700160709.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay PSR0700160709.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay PSR0700160709.hg.1 TC0700008582.hg.1 Clariom D TC
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay TC0700008582.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay PSR0700160708.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay PSR0700160708.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay PSR0700160708.hg.1 ENST00000223095.4 Ensembl
          Affymetrix Human Clariom D Assay PSR0700160708.hg.1 NM_000602.4 Refseq
          Affymetrix Human Clariom D Assay PSR0700160708.hg.1 TC0700008582.hg.1 Clariom D TC

          Back To Top
           

          Citations (20)

          Prediction of preeclampsia by analysis of cell-free messenger RNA in maternal plasma.
          Authors
          Purwosunu Y, Sekizawa A, Okazaki S, Farina A, Wibowo N, Nakamura M, Rizzo N, Saito H, Okai T
          Journal
          Am J Obstet Gynecol - Page No 3.86E+03 (Wed Apr 01 00:00:00 EDT 2009)
          Volume (Year)
          200 (2009)
          Product Usage
          -
          Microarray profiling of gene expression in human adipocytes in response to anthocyanins.
          Authors
          Tsuda T, Ueno Y, Yoshikawa T, Kojo H, Osawa T
          Journal
          Biochem Pharmacol - Page No 1184 (Fri Apr 14 00:00:00 EDT 2006)
          Volume (Year)
          71 (2006)
          Product Usage
          -
          Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors.
          Authors
          Fretz MM, Dolman ME, Lacombe M, Prakash J, Nguyen TQ, Goldschmeding R, Pato J, Storm G, Hennink WE, Kok RJ
          Journal
          J Control Release - Page No 200 (Thu Dec 18 00:00:00 EST 2008)
          Volume (Year)
          132 (2008)
          Product Usage
          -
          EGF-stimulated migration in ovarian cancer cells is associated with decreased internalization, increased surface expression, and increased shedding of the urokinase plasminogen activator receptor.
          Authors
          Henic E, Sixt M, Hansson S, Hoyer-Hansen G, Casslen B
          Journal
          Gynecol Oncol - Page No 28 (Sat Apr 01 00:00:00 EST 2006)
          Volume (Year)
          101 (2006)
          Product Usage
          -
          Comparative SAGE analysis of the response to hypoxia in human pulmonary and aortic endothelial cells.
          Authors
          Peters DG, Ning W, Chu TJ, Li CJ, Choi AM
          Journal
          Physiol Genomics - Page No 99 (Wed Jul 12 00:00:00 EDT 2006)
          Volume (Year)
          26 (2006)
          Product Usage
          -
          Pattern of expression of inflammatory markers in adipose tissue of untreated hypertensive patients.
          Authors
          Madec S, Chiarugi M, Santini E, Rossi C, Miccoli P, Ferrannini E, Solini A
          Journal
          J Hypertens - Page No 1459 (Thu Jul 01 00:00:00 EDT 2010)
          Volume (Year)
          28 (2010)
          Product Usage
          -
          Recurrent cytogenetic aberrations in central neurocytomas and their biological relevance.
          Authors
          Korshunov A, Sycheva R, Golanov A
          Journal
          Acta Neuropathol - Page No 303 (Thu Mar 01 00:00:00 EST 2007)
          Volume (Year)
          113 (2007)
          Product Usage
          -
          PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.
          Authors
          Fabre-Guillevin E, Malo M, Cartier-Michaud A, Peinado H, Moreno-Bueno G, Vallee B, Lawrence DA, Palacios J, Cano A, Barlovatz-Meimon G, Charriere-Bertrand C
          Journal
          Breast Cancer Res - Page No R100 (Tue Jan 01 00:00:00 EST 2008)
          Volume (Year)
          10 (2008)
          Product Usage
          -
          A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions.
          Authors
          Kimura H, Li X, Torii K, Okada T, Takahashi N, Fujii H, Ishihara S, Yoshida H
          Journal
          Nephrol Dial Transplant - Page No 2496 (Fri Aug 01 00:00:00 EDT 2008)
          Volume (Year)
          23 (2008)
          Product Usage
          -
          Introducing the cancer microenvironment section of Journal of Translational Medicine.
          Authors
          Vidal-Vanaclocha F, Witz IP
          Journal
          J Transl Med - Page No 60 (Fri Jan 01 00:00:00 EST 2010)
          Volume (Year)
          8 (2010)
          Product Usage
          -
          Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin.
          Authors
          Fu Q, Wang J, Boerma M, Berbee M, Qiu X, Fink LM, Hauer-Jensen M
          Journal
          Circ Res - Page No 369 (Fri Aug 15 00:00:00 EDT 2008)
          Volume (Year)
          103 (2008)
          Product Usage
          -
          The possibility of microarray-based analysis using cell-free placental mRNA in maternal plasma.
          Authors
          Miura K, Miura S, Yamasaki K, Shimada T, Kinoshita A, Niikawa N, Yoshiura K, Masuzaki H
          Journal
          Prenat Diagn - Page No 849 (Wed Sep 01 00:00:00 EDT 2010)
          Volume (Year)
          30 (2010)
          Product Usage
          -
          The -844 G/A PAI-1 polymorphism is associated with mRNA expression in rheumatoid arthritis.
          Authors
          Torres-Carrillo NM, Torres-Carrillo N, Vazquez-Del Mercado M, Delgado-Rizo V, Oregon-Romero E, Parra-Rojas I, Munoz-Valle JF
          Journal
          Rheumatol Int - Page No 355 (Fri Feb 01 00:00:00 EST 2008)
          Volume (Year)
          28 (2008)
          Product Usage
          -
          Endoglin expression in breast tumor cells suppresses invasion and metastasis and correlates with improved clinical outcome.
          Authors
          Henry LA, Johnson DA, Sarrio D, Lee S, Quinlan PR, Crook T, Thompson AM, Reis-Filho JS, Isacke CM
          Journal
          Oncogene - Page No (Mon Nov 01 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Genome-wide analysis of the endothelial transcriptome under short-term chronic hypoxia.
          Authors
          Ning W, Chu TJ, Li CJ, Choi AM, Peters DG
          Journal
          Physiol Genomics - Page No 70 (Thu Jun 17 00:00:00 EDT 2004)
          Volume (Year)
          18 (2004)
          Product Usage
          -
          Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein.
          Authors
          Nabarro S, Himoudi N, Papanastasiou A, Gilmour K, Gibson S, Sebire N, Thrasher A, Blundell MP, Hubank M, Canderan G, Anderson J
          Journal
          J Exp Med - Page No 1399 (Mon Nov 21 00:00:00 EST 2005)
          Volume (Year)
          202 (2005)
          Product Usage
          -
          Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes.
          Authors
          Shepard AR, Millar JC, Pang IH, Jacobson N, Wang WH, Clark AF
          Journal
          Invest Ophthalmol Vis Sci - Page No 2067 (Thu Apr 01 00:00:00 EDT 2010)
          Volume (Year)
          51 (2010)
          Product Usage
          -
          Cell-free mRNA concentrations of plasminogen activator inhibitor-1 and tissue-type plasminogen activator are increased in the plasma of pregnant women with preeclampsia.
          Authors
          Purwosunu Y, Sekizawa A, Koide K, Farina A, Wibowo N, Wiknjosastro GH, Okazaki S, Chiba H, Okai T
          Journal
          Clin Chem - Page No 399 (Thu Mar 01 00:00:00 EST 2007)
          Volume (Year)
          53 (2007)
          Product Usage
          -
          Transcriptional program induced by factor VIIa-tissue factor, PAR1 and PAR2 in MDA-MB-231 cells.
          Authors
          Albrektsen T, Sorensen BB, Hjorto GM, Fleckner J, Rao LV, Petersen LC
          Journal
          J Thromb Haemost - Page No 1588 (Wed Aug 01 00:00:00 EDT 2007)
          Volume (Year)
          5 (2007)
          Product Usage
          -
          Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells.
          Authors
          Li X, Kimura H, Hirota K, Kasuno K, Torii K, Okada T, Kurooka H, Yokota Y, Yoshida H
          Journal
          Kidney Int - Page No 569 (Mon Aug 01 00:00:00 EDT 2005)
          Volume (Year)
          68 (2005)
          Product Usage
          -

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