Orbitrap Excedion Series Mass Spectrometers | Thermo Fisher Scientific

Welcome to the next generation of hybrid Orbitrap mass spectrometry

Built on the advanced Excedion platform architecture, the Thermo Scientific Orbitrap Excedion Hybrid Mass Spectrometer delivers sensitive high-resolution, accurate-mass (HRAM) performance for metabolomics, lipidomics, MetID/DMPK, oligonucleotide, proteomics, environmental, and food safety research workflows.

Optimized ion optics—including an electrodynamic ion funnel and Advanced Quadrupole Technology (AQT)—combined with EASY-IC internal calibration provide exceptional mass accuracy, resolving power, and quantitative reliability. Enhanced Dynamic Range (eDR) MS¹ acquisition enables simultaneous detection of low- and high-abundance species in a single analysis.

With the option to upgrade in-lab to the Orbitrap Excedion Pro MS, the platform supports advanced biopharma characterization, deep proteomics, and structural biology with higher scan speeds, expanded mass range, Hybrid-DIA with adaptive RT, and optional fast and sensitive ETD/EThcD—protecting today’s investment while enabling tomorrow’s discoveries.

Orbitrap Excedion Series MS systems and applications

Confidently annotate MetID/DMPK

From accurate mass to confident identification—turn data into insight.

Explore MetID/DMPK

Reveal metabolomics & lipidomics insights

Uncover more biology with deeper, more sensitive metabolite detection.

Explore metabolomics & lipidomics

Deliver confident EFS results

Expand dynamic range for your Environmental & Food Safety (EFS) research. Amplify meaningful signal. Reveal what others miss.

Explore EFS contaminants

Exceed in Omics analysis

Unlock new possibilities in research and development. Discover the power of innovation and exceed your expectations.

Explore Orbitrap Excedion Pro

Elevate BioPharma characterization

Tailored for the biopharmaceutical industry, with advanced capabilities for discovery and development. Enabling deep insights and comprehensive characterization.

Explore BioPharma Edition

See data that enables discovery

Empowering groundbreaking discoveries in biopharma, metabolomics, proteomics, and structural biology applications.

Explore applications

Our general purpose product lines are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks.

For General Lab Use Only - Not For Diagnostic Procedures.

The Thermo Scientific Orbitrap Exploris and Excedion series mass spectrometers are Orbitrap instruments with an atmospheric pressure ionization (API) source for liquid chromatography (LC) mass spectrometry (MS) high-throughput applications. The instruments are designed to be placed on a bench in the laboratory and maintain mass accuracy across chromatographic peaks, supporting confident identification and quantitation using high-resolution accurate-mass detection.