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Cryo tomography workflow resources
Meet the scientists using Cryo-ET
"Cryo-tomography really shines because it's one of the few techniques that allows us to not only look at the details of the individual parts but also all of them holistically together."
Professor Danielle Grotjahn
Department of Integrative Structural and Computational Biology Scripps Research Institute
“The thing I love the most about this work is that every cell is different. It’s a glimpse into this unseen world and it’s always fascinating.”
Professor Ariane Briegel
Ultrastructural Biology, Leiden University
Co-director of NeCEN
“Electron tomography cannot only be used for our muscle research, but of course, you can imagine for cellular processes like septations or segregation of chromosomes or all kinds of different cellular aspects that really happen inside the cell and that you cannot reconstitute easily.”
Professor Stefan Raunser
Director of the Department of Structural Biochemistry
Max Planck Institute of Molecular Physiology
Dortmund, Germany
“We want to understand structure and function of cellular processes that are relevant for human health across scales. We can do this now here at Human Technopole. We can go from following the activity of macromolecular complexes by light microscopy to investigating their molecular structures within cells by cryo-ET or in isolation at higher resolution by single particle analysis to X-ray crystallography. We can cover the complete range of resolution.”
Professor Gaia Pigino
Human Technopole, Associate head of the Structural Biology Research Centre
“So with the workflow that we have now fully established at ISTA, we can really address a multitude of questions going from cell biology to high resolution structural biology all within a native context.”
Professor Florian Schur
Institute of Science and Technology Austria
Group Leader
Structural Biology of Cell Migration and viral Infection
ISTA