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Orbitrap Tribrid Apex Mass Spectrometer Systems

Reach new experimental heights with versatility, performance, and useability

Solve the most complex analytical challenges across small molecule, multiomics, structural biology, and biopharma research with the Thermo Scientific Orbitrap Tribrid Apex Mass Spectrometer.

With advanced ion control, flexible MSⁿ workflows, and orthogonal fragmentations, including infrared- and UV-enabled dissociation, the Orbitrap Tribrid Apex MS enables deeper structural insight across molecules ranging from proteins, metabolites, lipids  to macromolecular complexes.

Built on a field-upgradeable architecture, the platform evolves with your research, extending capability without compromise.

Discover features that will enable you to characterize challenging samples with precision and throughput to meaningfully expand what you can achieve.

What scientists are saying about Orbitrap Tribrid Apex MS

"Direct mass technology mode on the Orbitrap Tribrid Apex mass spectrometers opens an exciting frontier to obtain deep sequence coverage for proteoform targets with unparalleled sensitivity. This technology is highly versatile, and it is the best proteoform sequencer I’ve seen in my 25 years in translational research."

 

Prof. Neil Kelleher, Ph.D., Director, Northwestern Proteomics Center of Excellence, Northwestern University

"The Orbitrap Tribrid Apex mass spectrometers meaningfully expands what we can achieve in both small molecule and peptide characterization. The improved scan parallelization allows us to interrogate complex lipid species with greater depth, while the ability to tailor fragmentation strategies within a single platform is particularly powerful for proteomics, where structural heterogeneity demands analytical versatility. In particular, the new IR laser gives enhanced fragmentation flexibility for TMT report ions and glycoproteomics. These advances significantly improve our capacity to characterize challenging samples with precision and throughput."

 

Prof. Joshua Coon, Ph.D., Professor of Biomolecular Chemistry and Chemistry, University of Wisconsin-Madison

Explore each of the system highlights, including new options in hardware and software features

Small Molecule Edition

Reach the pinnacle of small molecule discovery, characterization, and quantitation.

BioPharma Edition

Reach new heights in biotherapeutic analyses from antibodies to oligonucleotides.

MultiOmics Edition

Rise to the molecular challenges of metabolomics and proteomics.

Structural Biology Edition

Elucidate more structural details of macromolecular complexes with ultimate versatility.

System highlights

Optimize less, gain structural insights faster

The optional IR-laser has proven benefits across a range of applications, from improving fragmentation quality when paired with ETD or improved signal-to-noise of TMT reporter ions to improving the desolvation of large native structures.

Isolate and detect large complexes without compromise

Extend Orbitrap mass range up to m/z 16,000 in MS1 and m/z 20,000 in MSn (n>1) levels. New quadrupole isolation range up to m/z 12,000.*

Elucidate the most complex samples for novel identifications

Single-ion detection allows for charge deconvolution without isotope or charge state patterns, allowing for complex analytes to be elucidated for identification and characterization.*

Detect deeper with more accuracy from scan-to-scan

Provides higher confidence identifications or quantification by triggering more informative MSn on-the-fly for peptide or small molecule analyses.

Never miss an identification due to mass error

Obtain sub-1ppm mass accuracy with internal calibration.

Radical fragmentation for more sequence characterization

Achieve high sequence coverage of proteins, including site localization of labile PTMs with Electron Transfer Dissociation (ETD).*

Orthogonal fragmentation for higher energy bond breakage

Gain new insights into molecular structures with ultraviolet (UV)-based fragmentation for small molecules, proteins, and other molecules. Alternately, the UV-laser can assist with excitation of molecules prior to other dissociative techniques, improving fragmentation in oligonucleotides.

Gain more insights into heterogenous spectra

Reduce m/z spectral complexity to enhance macromolecule characterization at MS1 and MS2 levels, with PTCR option.*

*available for MultiOmics, Structural Biology, and BioPharma editions only

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For Research Use Only. Not for use in diagnostic procedures.