Chemoproteomics Products

Kingfisher magnetic bead-based sample preparation or enrichment platform

Prepare samples efficiently from a variety of materials with the Thermo Scientific KingFisher Flex Purification System, which offers highly versatile, automated magnetic-particle processing for DNA/RNA, protein or cell purification from virtually any source. Using revolutionary magnetic particle separation technology, this system provides excellent reproducibility and quality.

FAIMS Pro Duo interface for experiments that require precise quantitation

For improved TMTpro quantitation, the Thermo Scientific FAIMS Pro Duo interface provides enhanced selectivity and sensitivity down to low picogram loading levels. High field asymmetric ion mobility technology separates peptides while simultaneously keeping the mass spectrometer clean and the spectra pure.

Vanquish Flex UHPLC System for high-throughput ligand screening analysis

Biocompatible with multiple detection options, Thermo Scientific Vanquish Flex UHPLC System provides excellent performance and flexibility and can be seamlessly coupled to a mass spectrometer. 

NativePac OBE-1 SEC Column for online sample preparation

Thermo Scientific NativePac OBE-1 Column is designed for rapid exchange of non-volatile buffer components with a volatile buffer for Native-MS analysis of biomacromolecules. The small pores of the SEC stationary phase maximize separation of the non-volatile components from the sample of interest while the short column length minimizes analysis times to less than 2 minutes.  

Orbitrap Astral Series Mass Spectrometers for experiments that require exceptional throughput and depth

For a new level of proteome depth and throughput, discover the Thermo Scientific Orbitrap Astral Series Mass Spectrometers. With industry-leading sensitivity and data quality, the platform can achieve coverage of over 8,300 proteins in less than 5 minutes to support high-throughput screening (HTS) projects.

Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer for experiments that require exceptional characterization and versatility

The Thermo Scientific Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer leverages exceptional versatility of analysis to characterize chemoproteomic samples. SPS-MS3 with real-time searching methods for TMT multiplexing enables accurate quantitation, deep coverage, and higher sample throughput.

Flexible fragmentation modes with CID, HCD, ETD, EtHCD and UVPD provide excellent results for PTM, top down, and crosslinking experiments. 

Orbitrap Excedion Pro Mass Spectrometer for experiments that require Orbitrap accuracy and enhanced selectivity for targeted quantitation

The Thermo Scientific Orbitrap Excedion Pro Mass Spectrometer offers proven reliability and spectral quality to support accurate quantitation performance.  The platform offers versatile operation to support DIA, TMT and targeted quantitation with high-resolution accurate mass PRM.

Q Exactive UHMR Mass Spectrometer equipped with Direct Mass Technology to decipher protein-ligand complex structure

For the investigation of structure and heterogeneity of protein-ligand bound complexes, the Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap Mass Spectrometer offers a powerful analytical solution. With its exceptional ability to perform native intact mass and top-down analyses, the Q Exactive UHMR Mass Spectrometer provides excellent structural detail which you cannot see with other methods, enabling deeper understanding of protein function, disease mechanisms, potential drug targets, and biotherapeutic compounds. The Thermo Scientific Direct Mass Technology Mode enables charge detection to deconvolute protein complexes, biotherapeutics, and viral particles that are too complex to resolve using ensemble methods.

Stellar Mass Spectrometer for experiments that require high sensitivity for targeted quantitation

The Thermo Scientific Stellar Mass Spectrometer offers industry leading speed and sensitivity for targeted quantitation to support lead validation and pre-clinical studies. It can support PRM assays for 10s-1000s of peptides using MS2 or MS3 ions.

Ardia Platform: Software that supports your digital transformation journey

The Thermo Scientific Ardia Platform is a scalable software solution for modern, dynamic and often cloud-based environments that connects and organizes projects, people, and instruments on a global level. The web-based access and secure centralized data storage enables scientists to collaborate more efficiently and gain new insights faster, helping them get closer to the truth.

Proteome Discoverer Software for experiments that require flexible data analysis

Thermo Scientific Proteome Discoverer Software offers predefined workflows to support both DIA and TMT quantitation. With CHIMERYS intelligent search algorithm by MSAID for DIA analysis, it supports fractionated TMT samples and data visualization with volcano plots, PCA and spectra.

Compound Discoverer Software for comprehensive metabolite characterization

Save time for your metabolite identification studies. Thermo Scientific Compound Discoverer Software helps ensure confident compound identification and structural elucidation for pharmaceutical metabolism studies as well as aiding impurity analysis. The software helps researchers plan how data will be collected, organized, stored and reported with the final result in mind. Its node-assembled processing workflows, advanced algorithms, and study-oriented data storage allow users to quickly process and assemble data collected from multiple samples into a unified report.

BioPharma Finder Software

Thermo Scientific BioPharma Finder Software supports MS based intact protein data analysis as well as peptide identification, PTM analysis and quantification for protein characterization or protein-ligand binding verification.