imPULSE Single-Use Mixer

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Innovative technology built for superior mixing

The imPULSE Single-Use Mixer (S.U.M.) can be utilized for many bioprocess mixing applications. The imPULSE design features include innovative disc mixing technology, configurable high-end controls, and monitors to fit specific process requirements. Combined, these features enable uniform, superior mixing—scalable from 30 L to 5,000 L. The Touchscreen Console for the imPULSE S.U.M. facilitate superior integrated sensor monitoring, and pump control for pH and saline titration and for automatic fill and harvest of the S.U.M.

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Mixing technology key features

  • Available in 30, 100, 250, 500, 1,000, 2,000, 3,000 and 5,000 L
  • Touchscreen Console provides ease-of-use with multi-functional capabilities to monitor and control mixing parameters
  • Integrated rolling diaphragm that provides the pumping action to the mixing disc; the diaphragm will not abrade the surfaces or produce particulate
  • Mixing tank jacket and insulation
  • Weighing systems that utilize load cells enable accurate batch weight monitoring
  • Auto inflate and vent control options
  • Adjustable powder port for 1,000 L and higher that fits 1, 5, and 25 kg Powdertainer BPCs
  • Open cart frame for easier cleaning

Areas of application

  • Media preparation
  • Final formulation steps
  • Buffer preparation
  • Harvest vessels
  • Large-volume mixing
  • Pooling and transfer
  • Resuspension
  • Mixing and storing multiple batches
  • Viral inactivation

Mixing technology

The disc is an integrated part of the single-use BPC and is designed with slots and silicone flaps. The moving disc creates a pulsing action that has two effects:

  • On the upstroke, the flaps open as the disc moves up from the bottom of the mixing bag and fluid flows through the slots of the disc.
  • On the downstroke, the flaps close as the disc moves down and energy is directed down and channeled through the space between the mixing disc profile and the vessel side walls.

As a result, the velocity of the displaced liquid provides robust mixing.
 

Rolling diaphragm: Provides an interface between the BPC and the movable shaft with the mixing disc. There are no contact surfaces between the side walls and the diaphragm; therefore, the system does not generate particulates.

 

Linear scalability: The imPULSE mixing disc diameter increases proportionally as the size of the vessel increases. The ratio of the displaced liquid volume to the vessel volume is the same from all sizes ranging from 30 L to 5,000 L. This enables consistent and reproducible results, as processes are easily scaled up across all sizes.

Help mitigate risk with Thermo Scientific BioProcess Containers (BPCs) and BioTitan

The Thermo Scientific imPULSE Single-Use Mixer (S.U.M.) BioProcess Container (BPC) is a 3D system now available in our robust Aegis3-14 film as well as ASI 26/77 film.  ImPULSE BPCs aim to eliminate post-use cleaning steps required with reusable containers and help reduce cross-contamination risks.

The BioTitan Retention Device—an innovative replacement to traditional cable ties—offers a 360-degree seal, available for use on all imPULSE single-use mixers.

imPULSE Mixer Touchscreen Console

While maintaining a traditional approach to measurements and controls on S.U.M.s, the imPULSE Mixer Touchscreen Console offers advanced monitoring, automated mixing recipes, pump control for pH and saline titration, as well as automatic fill and harvest of the S.U.M.

Key advantages:

The main screen is populated with user-selectable modules, which allow for screen customization. Modules include:

  • Agitation
  • Mass
  • Temperature
  • Timer
  • pH
  • Conductivity
  • Pump control
  • BPC pressure
  • Liquid pressure
  • Automated and metered fill and harvest
  • Auxiliary input
  • PDC module

Featured videos

The imPULSE S.U.M. System is ideal for a wide range of liquid-to-liquid or powder-to-liquid mixing applications, utilizing an innovative mixing disc technology and customizable BPCs.

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Single-Use Bioprocessing Equipment and Automation

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Single-Use Bioprocessing

Our innovative single-use technologies enable you to accelerate biological manufacturing processes to create flexibility and operate more dynamically within upstream and downstream workflows.

BioProcessing Containers and Nalgene Bottles

We offer high-quality storage, transport, and sampling solutions, including Thermo Scientific BioProcess Containers (BPCs) and Thermo Scientific Nalgene containers.
 

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For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.