Product References
Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium-Induced Colitis.
Cellular and molecular gastroenterology and hepatology
Lee Y,Kim SH,Jeong H,Kim KH,Jeon D,Cho Y,Lee D,Nam KT
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Immunohistochemistry
Tue Aug 22 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo.
Molecular medicine reports
Huo J,Liu T,Li F,Song X,Hou X
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.
JCI insight
Yun JH,Lee C,Liu T,Liu S,Kim EY,Xu S,Curtis JL,Pinello L,Bowler RP,Silverman EK,Hersh CP,Zhou X
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Wed Sep 08 00:00:00 EDT 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-1271-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 EDT 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells.
Nature immunology
Twohig JP,Cardus Figueras A,Andrews R,Wiede F,Cossins BC,Derrac Soria A,Lewis MJ,Townsend MJ,Millrine D,Li J,Hill DG,Uceda Fernandez J,Liu X,Szomolay B,Pepper CJ,Taylor PR,Pitzalis C,Tiganis T,Williams NM,Jones GW,Jones SA
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Mon Apr 01 00:00:00 EDT 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-1271-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 EDT 2019
Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.
Haematologica
Zhang Z,Huang Z,Ong B,Sahu C,Zeng H,Ruan HB
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2019
Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8+ T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection.
Immune network
Son J,Cho YW,Woo YJ,Baek YA,Kim EJ,Cho Y,Kim JY,Kim BS,Song JJ,Ha SJ
14-1271-82 was used in Flow Cytometry to understand the level of AMP-activated protein kinase activation required for optimal memory T cell differentiation.
Mon Apr 01 00:00:00 EDT 2019
Extrinsic Acquisition of CD80 by Antigen-Specific CD8+ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection.
Immune network
Son J,Ha SJ
14-1271-82 was used in Flow Cytometry to investigate the origin and physiological role of CD80 on CD8+ T cells.
Thu Aug 01 00:00:00 EDT 2019
Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells.
Cell reports
Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Tue Dec 03 00:00:00 EST 2019
Direct interaction of whole-inactivated influenza A and pneumococcal vaccines enhances influenza-specific immunity.
Nature microbiology
David SC,Norton T,Tyllis T,Wilson JJ,Singleton EV,Laan Z,Davies J,Hirst TR,Comerford I,McColl SR,Paton JC,Alsharifi M
14-1271 was used in Flow cytometry/Cell sorting to provide an additional explanation for the synergistic pathogenicity of IAV and S. pneumoniae, as well as heralding the prospect of exploiting the phenomenon to develop better vaccine strategies for both pathogens.
Thu Aug 01 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-1271 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.
ImmunoHorizons
Poholek CH,Dulson SJ,Zajac AJ,Harrington LE
14-1271 was used in Flow cytometry/Cell sorting to reveal a novel role for IL-21 in shaping innate lymphoid cell responses in the intestine and provide one mechanism by which effector CD4 T cells can influence innate immunity.
Tue Jun 04 00:00:00 EDT 2019
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-1271 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.
The Journal of experimental medicine
Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE
14-1271 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.
Mon Jul 02 00:00:00 EDT 2018
Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2.
The Journal of experimental medicine
Koga S,Hozumi K,Hirano KI,Yazawa M,Terooatea T,Minoda A,Nagasawa T,Koyasu S,Moro K
14-1271 was used in Flow cytometry/Cell sorting to suggest that early differentiation of ILC2 occurs in the fetal liver via IL-7 and Notch signaling, whereas final differentiation occurs in the periphery with the aid of PDGFRα+gp38+ cells.
Mon Jun 04 00:00:00 EDT 2018
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-1271 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 EDT 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Constitutive Activation of NF-κB Pathway in Hematopoietic Stem Cells Causes Loss of Quiescence and Deregulated Transcription Factor Networks.
Frontiers in cell and developmental biology
Nakagawa MM,Chen H,Rathinam CV
14-1271 was used in Flow cytometry/Cell sorting to demonstrate that aberrant activation of NF-κB signals impairs haematopoietic stem cells quiescence and functions, and alters the 'transcription factors networks' in HSCs.
Thu Oct 01 00:00:00 EDT 2020
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
14-1271 was used in Flow cytometry/Cell sorting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.
Thu Feb 15 00:00:00 EST 2018
The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion.
International journal of molecular medicine
Luo B,Chen K,Feng Q,Xiao W,Ma D,Yang H,Zhang C
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2018
MicroRNA 33 Regulates the Population of Peripheral Inflammatory Ly6Chigh Monocytes through Dual Pathways.
Molecular and cellular biology
Baba O,Horie T,Nakao T,Hakuno D,Nakashima Y,Nishi H,Kuwabara Y,Nishiga M,Nishino T,Ide Y,Nakazeki F,Koyama S,Kimura M,Hanada R,Kawahara M,Kimura T,Ono K
14-1271 was used in Flow cytometry/Cell sorting to indicate that miR-33 deficiency affects distribution of inflammatory monocytes through dual pathways.
Sun Jul 15 00:00:00 EDT 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Wed Mar 28 00:00:00 EDT 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
Mon May 28 00:00:00 EDT 2018
Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis.
Science advances
Zeng H,Yu M,Tan H,Li Y,Su W,Shi H,Dhungana Y,Guy C,Neale G,Cloer C,Peng J,Wang D,Chi H
14-1271 was used in Flow cytometry/Cell sorting to determine the mechanism by which interleukin-7 in early B lymphopoeisis and the role of Stat5-dependent and independent pathways in this process.
Mon Jan 01 00:00:00 EST 2018
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
14-1271 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 EST 2018
STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.
Scientific reports
Alshekaili J,Chand R,Lee CE,Corley S,Kwong K,Papa I,Fulcher DA,Randall KL,Leiding JW,Ma CS,Wilkins MR,Uzel G,Goodnow CC,Vinuesa CG,Tangye SG,Cook MC
14-1271 was used in Flow cytometry/Cell sorting to show that changes in blood and germinal centre cytotoxicity might be affected by changes in STAT3 signalling or modulation of PD-1 by therapy.
Fri Feb 23 00:00:00 EST 2018
Translation is actively regulated during the differentiation of CD8+ effector T cells.
Nature immunology
Araki K,Morita M,Bederman AG,Konieczny BT,Kissick HT,Sonenberg N,Ahmed R
14-1271 was used in Flow cytometry/Cell sorting to characterise the translatome of virus-specific CD8+ effector T cells during acute infection of mice with lymphocytic choriomeningitis virus.
Fri Sep 01 00:00:00 EDT 2017
Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone.
The Journal of allergy and clinical immunology
Ramirez-Carrozzi V,Sambandam A,Zhou M,Yan D,Kang J,Wu X,Suto E,Baca M,Austin C,Xu M,Lee W,Pappu R
14127182 was used in flow cytometry to study the effect of IL-13 and IL-33 pathways in dysregulated type 2 inflammation.
Wed Feb 01 00:00:00 EST 2017
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.
The EMBO journal
Guidi N,Sacma M,Ständker L,Soller K,Marka G,Eiwen K,Weiss JM,Kirchhoff F,Weil T,Cancelas JA,Florian MC,Geiger H
14127182 was used in flow cytometry to examine the contribution of stroma-derived osteopontin for hematopoietic stem cell aging
Mon Apr 03 00:00:00 EDT 2017
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
14-1271-82 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 EDT 2017
IL-7 Induces an Epitope Masking of γc Protein in IL-7 Receptor Signaling Complex.
Mediators of inflammation
Goh TS,Jo Y,Lee B,Kim G,Hwang H,Ko E,Kang SW,Oh SO,Baek SY,Yoon S,Lee JS,Hong C
14-1271 was used in Flow cytometry/Cell sorting to demonstrate here that 4G3, TUGm2, and 3E12 epitope masking of γc protein are induced in the presence of IL-7, indicating that the epitope alteration is induced by IL-7 binding to the preassembled receptor core.
Mon Aug 14 00:00:00 EDT 2017
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence.
Nature
Ibiza S,García-Cassani B,Ribeiro H,Carvalho T,Almeida L,Marques R,Misic AM,Bartow-McKenney C,Larson DM,Pavan WJ,Eberl G,Grice EA,Veiga-Fernandes H
14127182 was used in flow cytometry to explain how glial cells impact ILC3-derived IL-22
Thu Jul 21 00:00:00 EDT 2016
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nature immunology
Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D
14-1271 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.
Wed Jun 01 00:00:00 EDT 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-1271 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 EDT 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
14-1271 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.
Fri Apr 01 00:00:00 EDT 2016
Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.
Proceedings of the National Academy of Sciences of the United States of America
Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK
14-1271 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.
Tue Feb 09 00:00:00 EST 2016
Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells.
Cancer immunology, immunotherapy : CII
Foy SP,Mandl SJ,dela Cruz T,Cote JJ,Gordon EJ,Trent E,Delcayre A,Breitmeyer J,Franzusoff A,Rountree RB
14-1271 was used in Flow cytometry/Cell sorting to help elucidate evidence of enhanced clinical benefit from combining CTLA-4 blockade with poxvirus-based active immunotherapy.
Sun May 01 00:00:00 EDT 2016
Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE
14-1271 was used in Flow cytometry/Cell sorting to suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.
Fri Jan 15 00:00:00 EST 2016
lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets.
Journal of immunology (Baltimore, Md. : 1950)
Carow B,Gao Y,Coquet J,Reilly M,Rottenberg ME
14127182 was used in flow cytometry to implement lck-cre transgenic mice to study the role of loxP-targeted genes in T cell development and function
Thu Sep 15 00:00:00 EDT 2016
General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.
Journal of neuroimmunology
Keil M,Sonner JK,Lanz TV,Oezen I,Bunse T,Bittner S,Meyer HV,Meuth SG,Wick W,Platten M
14127182 was used in flow cytometry to investigate the role of general control non-derepressible 2 in resolving autoimmune neuroinflammation
Mon Aug 15 00:00:00 EDT 2016
A simple, accurate and universal method for quantification of PCR.
BMC biotechnology
Boulter N,Suarez FG,Schibeci S,Sunderland T,Tolhurst O,Hunter T,Hodge G,Handelsman D,Simanainen U,Hendriks E,Duggan K
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Wed Mar 09 00:00:00 EST 2016
Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Nature communications
Li Z,Hodgkinson T,Gothard EJ,Boroumand S,Lamb R,Cummins I,Narang P,Sawtell A,Coles J,Leonov G,Reboldi A,Buckley CD,Cupedo T,Siebel C,Bayat A,Coles MC,Ambler CA
14-1271 was used in Flow cytometry/Cell sorting to invesitgate whether Notch directs non-cell-autonomous signalling in adult tissues, showing that it recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Thu Apr 21 00:00:00 EDT 2016
GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
Cell death & disease
Le Q,Yao W,Chen Y,Yan B,Liu C,Yuan M,Zhou Y,Ma L
14127182 was used in flow cytometry to use knockout mice to determine if GRK6 contributes to hematopoiesis
Thu Nov 24 00:00:00 EST 2016
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Nature immunology
Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage.
The Journal of experimental medicine
Aparicio-Domingo P,Romera-Hernandez M,Karrich JJ,Cornelissen F,Papazian N,Lindenbergh-Kortleve DJ,Butler JA,Boon L,Coles MC,Samsom JN,Cupedo T
14-1271 was used in Flow cytometry/Cell sorting to investigate the cellular mechanisms that control tissue protection and mucosal healing in response to intestinal damage.
Mon Oct 19 00:00:00 EDT 2015
Increased Immune Response Variability during Simultaneous Viral Coinfection Leads to Unpredictability in CD8 T Cell Immunity and Pathogenesis.
Journal of virology
Kenney LL,Cornberg M,Chen AT,Emonet S,de la Torre JC,Selin LK
14-1271 was used in Flow cytometry/Cell sorting to investigate how competition between immune responses to two viruses would influence the development of CD8 T cell memory and subsequent disease outcome.
Sun Nov 01 00:00:00 EDT 2015
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-1271 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Nature immunology
Xu X,Araki K,Li S,Han JH,Ye L,Tan WG,Konieczny BT,Bruinsma MW,Martinez J,Pearce EL,Green DR,Jones DP,Virgin HW,Ahmed R
14-1271 was used in Flow cytometry/Cell sorting to show that autophagy is dynamically regulated in virus-specific CD8 T-cells during acute lymphocytic choriomeningitis virus infection.
Mon Dec 01 00:00:00 EST 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-1271 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-1271 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
The Journal of experimental medicine
Penaloza-MacMaster P,Kamphorst AO,Wieland A,Araki K,Iyer SS,West EE,O'Mara L,Yang S,Konieczny BT,Sharpe AH,Freeman GJ,Rudensky AY,Ahmed R
14-1271 was used in Flow cytometry/Cell sorting to investigate a role for T reg cells in exhaustion of virus-specific CD8 T cells.
Mon Aug 25 00:00:00 EDT 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
14-1271 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.
Mon Apr 07 00:00:00 EDT 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-1271 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 EDT 2014
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.
eLife
Han BY,Wu S,Foo CS,Horton RM,Jenne CN,Watson SR,Whittle B,Goodnow CC,Cyster JG
14-1271 was used in Flow cytometry/Cell sorting to characterise the phenotype of a mutant mouse exhibiting a mutated zinc finger protein.
Fri Oct 24 00:00:00 EDT 2014
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.
European journal of immunology
Brinkhoff B,Ostroumov D,Heemcke J,Woller N,Gürlevik E,Manns MP,Longerich T,Zender L,Harty JT,Kubicka S,Kühnel F,Wirth TC
14-1271-82 was used in Flow Cytometry to develop a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid microspheres followed by booster vaccination with Listeria monocytogenes vectors.
Tue Apr 01 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-1271-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.
Nature immunology
Keating R,Hertz T,Wehenkel M,Harris TL,Edwards BA,McClaren JL,Brown SA,Surman S,Wilson ZS,Bradley P,Hurwitz J,Chi H,Doherty PC,Thomas PG,McGargill MA
14-1271 was used in Flow cytometry/Cell sorting to investigate the immunological mechanisms that promote heterosubtypic immunity, showing that mTOR modulates the antibody response to provide cross-protective immunity to lethal infection.
Sun Dec 01 00:00:00 EST 2013
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
The Journal of experimental medicine
Kirchberger S,Royston DJ,Boulard O,Thornton E,Franchini F,Szabady RL,Harrison O,Powrie F
14-1271 was used in Flow cytometry/Cell sorting to describe a new role of IL-22 in the colon as a non-redundant mediator of the inflammatory cascade necessary for the continuation of colorectal cancer.
Mon May 06 00:00:00 EDT 2013
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.
The Journal of experimental medicine
Kirchberger S,Royston DJ,Boulard O,Thornton E,Franchini F,Szabady RL,Harrison O,Powrie F
14-1271 was used in Flow cytometry/Cell sorting to describe a new role of IL-22 in the colon as a non-redundant mediator of the inflammatory cascade necessary for the continuation of colorectal cancer.
Mon May 06 00:00:00 EDT 2013
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine
Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH
14-1271 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.
Fri Nov 01 00:00:00 EDT 2013
Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population.
Infection and immunity
Bhadra R,Cobb DA,Khan IA
14-1271 was used in Flow cytometry/Cell sorting to determine if treatment with exogenous CD8+ T cells can rescue the endogenous population during Toxoplasma gondii infection.
Sun Sep 01 00:00:00 EDT 2013
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
PloS one
Li G,Yang Q,Zhu Y,Wang HR,Chen X,Zhang X,Lu B
14-1271 was used in Flow cytometry/Cell sorting to investigate the role of T-bet and Eomes in shaping the memory T cell pool.
Tue Oct 10 00:00:00 EDT 2017
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation.
Nature immunology
Ochiai K,Maienschein-Cline M,Mandal M,Triggs JR,Bertolino E,Sciammas R,Dinner AR,Clark MR,Singh H
Published figure using CD127 monoclonal antibody (Product # 14-1271-82) in Flow Cytometry
Sun Jan 22 00:00:00 EST 2012
Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Courtial N,Smink JJ,Kuvardina ON,Leutz A,Göthert JR,Lausen J
14-1271 was used in Flow cytometry/Cell sorting to show that Tal1 is expressed in osteoclasts and that loss of Tal1 in osteoclast progenitors leads to altered expression of >1200 genes.
Wed Feb 01 00:00:00 EST 2012
Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Li Q,Rao R,Vazzana J,Goedegebuure P,Odunsi K,Gillanders W,Shrikant PA
14-1271 was used in Flow cytometry/Cell sorting to indicate that judicious application of rapamycin can augment vaccine efficacy for chronic challenges.
Sun Apr 01 00:00:00 EDT 2012
Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Martin MD,Condotta SA,Harty JT,Badovinac VP
14-1271 was used in Flow cytometry/Cell sorting to investigate cell-autonomous functional differences between naive and memory CD8 T cells.
Wed Feb 01 00:00:00 EST 2012
T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen.
Journal of immunology (Baltimore, Md. : 1950)
Bou Ghanem EN,Nelson CC,D'Orazio SE
14-1271 was used in Flow cytometry/Cell sorting to demonstrate that the microenvironment in L. monocytogenes-infected BALB/c mice is sufficient to induce responsive CD8(+) T cells to rapidly secrete IFN-γ.
Tue Feb 01 00:00:00 EST 2011
Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression.
Blood
Drissen R,Guyot B,Zhang L,Atzberger A,Sloane-Stanley J,Wood B,Porcher C,Vyas P
14-1271 was used in Flow cytometry/Cell sorting to seek an enhancer element upstream of the Gata1 gene that specifically directs erythroid expression.
Thu Apr 29 00:00:00 EDT 2010
MHC class I-deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment.
The Journal of experimental medicine
Elliott JM,Wahle JA,Yokoyama WM
14-1271 was used in Flow cytometry/Cell sorting to investigate whether licensing is developmentally determined in the bone marrow, showing that MHC class I ligands are not absolutely required for licensing.
Mon Sep 27 00:00:00 EDT 2010
Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.
PLoS pathogens
Schmidt NW,Butler NS,Badovinac VP,Harty JT
14-1271 was used in Flow cytometry/Cell sorting to identify and track whole-parasite, RAS-vaccine-induced effector and memory CD8 T cell responses.
Thu Jul 15 00:00:00 EDT 2010
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
PLoS pathogens
Wilson DC,Grotenbreg GM,Liu K,Zhao Y,Frickel EM,Gubbels MJ,Ploegh HL,Yap GS
14-1271 was used in Flow cytometry/Cell sorting to identify a novel H-2K(b)-restricted CTL population specific for the Toxoplasma antigen tgd057.
Fri Mar 19 00:00:00 EDT 2010
Predicting CD62L expression during the CD8+ T-cell response in vivo.
Immunology and cell biology
Schlub TE,Badovinac VP,Sabel JT,Harty JT,Davenport MP
14-1271 was used in Flow cytometry/Cell sorting to investigate whether there is a relationship between CD62L expression and cell division.
Mon Feb 01 00:00:00 EST 2010
The role of skin-derived dendritic cells in CD8+ T cell priming following immunization with lentivectors.
Journal of immunology (Baltimore, Md. : 1950)
Furmanov K,Elnekave M,Lehmann D,Clausen BE,Kotton DN,Hovav AH
14-1271 was used in Flow cytometry/Cell sorting to study antigen presentation to CD8(+) T cells, after intradermal immunisation with lentivectors.
Sat May 01 00:00:00 EDT 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-1271 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 EDT 2010
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.
Nature immunology
McGeachy MJ,Chen Y,Tato CM,Laurence A,Joyce-Shaikh B,Blumenschein WM,McClanahan TK,O'Shea JJ,Cua DJ
14-1271 was used in Flow cytometry/Cell sorting to investigate the requirement for IL-23 signaling in the development and function of T(H)-17 cells in autoimmunity, inflammation and infection.
Sun Mar 01 00:00:00 EST 2009
MLL5 contributes to hematopoietic stem cell fitness and homeostasis.
Blood
Zhang Y,Wong J,Klinger M,Tran MT,Shannon KM,Killeen N
14-1271 was used in Flow cytometry/Cell sorting to show that inactivation of the Mll5 gene in mice results in the reduction in frequency and function of haematopoietic stem cells.
Thu Feb 12 00:00:00 EST 2009
Cytokine-induced memory-like natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America
Cooper MA,Elliott JM,Keyel PA,Yang L,Carrero JA,Yokoyama WM
14-1271 was used in Flow cytometry/Cell sorting to identify an ability of innate immune cells to retain an intrinsic memory of prior activation.
Tue Feb 10 00:00:00 EST 2009
Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Min B
14-1271 was used in Flow cytometry/Cell sorting to investigate the conditions and requirements of MHC and DCs for endogenous proliferation of different T-cell subsets.
Tue Dec 01 00:00:00 EST 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-1271 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.
Journal of immunology (Baltimore, Md. : 1950)
Vondenhoff MF,Greuter M,Goverse G,Elewaut D,Dewint P,Ware CF,Hoorweg K,Kraal G,Mebius RE
Fri May 01 00:00:00 EDT 2009
Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens.
Journal of immunology (Baltimore, Md. : 1950)
Kastenmuller W,Gasteiger G,Stross L,Busch DH,Drexler I
14-1271-82 was used in Flow Cytometry to demonstrate the potency of a simple needle-free vaccination, combining the advantages of mucosal application with the stability and efficiency of lyophilised modified vaccinia virus Ankara.
Sun Mar 01 00:00:00 EST 2009
In vivo expression of signaling proteins in reconstituted NK cells.
Journal of immunological methods
Orr SJ,Quigley L,McVicar DW
14-1271 was used in Flow cytometry/Cell sorting to develop a novel technique to generate NK cells in vivo, all of which express a gene of interest.
Fri Jan 30 00:00:00 EST 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
14-1271 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
Long-lived virus-reactive memory T cells generated from purified cytokine-secreting T helper type 1 and type 2 effectors.
The Journal of experimental medicine
Löhning M,Hegazy AN,Pinschewer DD,Busse D,Lang KS,Höfer T,Radbruch A,Zinkernagel RM,Hengartner H
14-1271 was used in Flow cytometry/Cell sorting to investigate the generation of memory cells from purified cytokine-secreting Th1 and Th2 effector T cells following their adoptive transfer into normal mice.
Mon Jan 21 00:00:00 EST 2008
IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.
PLoS pathogens
Couper KN,Blount DG,Wilson MS,Hafalla JC,Belkaid Y,Kamanaka M,Flavell RA,de Souza JB,Riley EM
14-1271 was used in Flow cytometry/Cell sorting to investigate the cellular source of IL-10 and TGF-beta during malaria infection, showing that IL-10 from CD4+CD25-Foxp3-CD127- adaptive Tregs modulates parasite clearance and pathology.
Fri Feb 29 00:00:00 EST 2008
Identification of CD4int progenitors in mouse fetal spleen, a source of resident lymphoid cells.
Journal of leukocyte biology
Desanti GE,Cumano A,Golub R
14-1271 was used in Flow cytometry/Cell sorting to propose a model for fetal splenic hematopoietic progenitors and their distribution.
Thu May 01 00:00:00 EDT 2008
Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication.
Journal of immunology (Baltimore, Md. : 1950)
Lang A,Brien JD,Messaoudi I,Nikolich-Zugich J
14-1271 was used in Flow cytometry/Cell sorting to investigate the correlation between latent herpesvirus infection with immune exhaustion and shorter lifespan.
Tue Apr 01 00:00:00 EDT 2008
Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling.
Blood
Kohara H,Omatsu Y,Sugiyama T,Noda M,Fujii N,Nagasawa T
14-1271 was used in Immunofluorescence to provide evidence to show that CXCL12 is an important regulator of plasmacytoid dendritic cell development.
Sat Dec 15 00:00:00 EST 2007
Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling.
Cancer research
Brown VI,Hulitt J,Fish J,Sheen C,Bruno M,Xu Q,Carroll M,Fang J,Teachey D,Grupp SA
14-1271 was used in in vitro experiments to examine the effect of thymic stromal-derived lymphopoietin on precursor B acute lymphoblastic leukaemia cells and their response to mTOR inhibitors.
Mon Oct 15 00:00:00 EDT 2007
Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling.
Cancer research
Brown VI,Hulitt J,Fish J,Sheen C,Bruno M,Xu Q,Carroll M,Fang J,Teachey D,Grupp SA
14-1271 was used in in vitro experiments to examine the effect of thymic stromal-derived lymphopoietin on precursor B acute lymphoblastic leukaemia cells and their response to mTOR inhibitors.
Mon Oct 15 00:00:00 EDT 2007
The impact of a boosting immunogen on the differentiation of secondary memory CD8+ T cells.
Journal of virology
Hovav AH,Panas MW,Osuna CE,Cayabyab MJ,Autissier P,Letvin NL
14-1271 was used in Flow cytometry/Cell sorting to evaluate the effect of three different immunogens on the generation of memory cellular immune responses.
Sat Dec 01 00:00:00 EST 2007
Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Hovav AH,Panas MW,Rahman S,Sircar P,Gillard G,Cayabyab MJ,Letvin NL
14-1271 was used in Flow cytometry/Cell sorting to investigate the duration of Ag expression on pathogen-induced CD8(+) T cell response.
Thu Nov 15 00:00:00 EST 2007
Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutrition.
American journal of physiology. Gastrointestinal and liver physiology
Yang H,Sun X,Haxhija EQ,Teitelbaum DH
14-1271 was used in Flow cytometry/Cell sorting to study whether total parenteral nutrition diminishes epithelial cell-derived IL-7 expression and contributes to alterations in the intraepithelial lymphocyte population.
Mon Jan 01 00:00:00 EST 2007
Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2.
Cellular immunology
Van de Wiele CJ,Marino JH,Tan C,Kneale HA,Weber J,Morelli JN,Davis BK,Taylor AA,Teague TK
14-1271 was used in Flow cytometry/Cell sorting to evaluate the role of IL-7 signalling in early thymocyte development using transgenic IL-7Rα mice.
Mon May 19 00:00:00 EDT 2008
Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection.
The Journal of experimental medicine
Yu Q,Park JH,Doan LL,Erman B,Feigenbaum L,Singer A
14-1271 was used in Flow cytometry/Cell sorting to show that IL-7R signalling is blocked in CD4+8+ double-positive thymocytes by suppressor of cytokine signaling (SOCS)-1.
Mon Jan 23 00:00:00 EST 2006
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.
Proceedings of the National Academy of Sciences of the United States of America
Coles MC,Veiga-Fernandes H,Foster KE,Norton T,Pagakis SN,Seddon B,Kioussis D
14-1271 was used in Flow cytometry/Cell sorting to reveal a potential role for mature lymphocytes and IL7/IL7r interactions in postnatal lymph node development.
Tue Sep 05 00:00:00 EDT 2006
Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.
The American journal of pathology
Leithäuser F,Meinhardt-Krajina T,Fink K,Wotschke B,Möller P,Reimann J
Thu Jun 01 00:00:00 EDT 2006