Invitrogen

CD127 Monoclonal Antibody (A7R34), PE-Cyanine7, eBioscience™

图: 1 / 19

CD127 Antibody (25-1271-82) in Flow

Staining of BALB/c splenocytes with Anti-Mouse CD3e FITC (Product # 11-0031-82) and 1.0 µg of Rat IgG2a K Isotype Control PE-Cyanine7 (Product # 25-4321-82) (left) or 1.0 µg of Anti-Mouse CD127 PE-Cyanine7 (right). Cells in the lymphocyte gate were used for analysis.

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产品信息

25-1271-82

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

1 µg/test

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产品规格

种属反应

Mouse

已发表种属

Human, Mouse

宿主/亚型

Rat / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

A7R34

偶联物

PE-Cyanine7 PE-Cyanine7 PE-Cyanine7

激发/发射光谱

569/780 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_469649

产品详细信息

Description: The A7R34 monoclonal antibody reacts with mouse CD127, the high affinity alpha subunit of the mouse IL-7 receptor. IL-7 receptor alpha chain is expressed by immature B cells in the bone marrow, double-negative (CD4-CD8-), single-positive (CD4+ and CD8+), but not double-positive (CD4+CD8+) thymocytes. In the periphery, mature T cells express CD127 at low level. A7R34 inhibits binding of IL-7 to its receptor and has been used in in vivo and in vitro studies to elucidate the role of IL-7 in T and B cell development and activation. Binding of A7R34 blocks the binding of SB/199, another antibody which recognizes mouse CD127.

Applications Reported: The A7R34 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This A7R34 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Journal of immunology (Baltimore, Md. : 1950)

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25-1271 was used in Flow cytometry/Cell sorting to report that Foxn1 is expressed in wild-type BM and overexpressed in Foxn1Tg.

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IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.

Journal of immunology (Baltimore, Md. : 1950)

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25-1271 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.

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RAG-1 and Ly6D independently reflect progression in the B lymphoid lineage.

PloS one

Zhang Q,Esplin BL,Iida R,Garrett KP,Huang ZL,Medina KL,Kincade PW

25-1271 was used in Flow cytometry/Cell sorting to elucidate the mechanisms regulating the differentiation path from haematopoietic stem cells to B lineage lymphocytes.

Tue Apr 15 00:00:00 EDT 2014

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation.

Nature immunology

Ochiai K,Maienschein-Cline M,Mandal M,Triggs JR,Bertolino E,Sciammas R,Dinner AR,Clark MR,Singh H

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Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells.

Journal of immunology (Baltimore, Md. : 1950)

Iyer SS,Chatraw JH,Tan WG,Wherry EJ,Becker TC,Ahmed R,Kapasi ZF

25-1271 was used in Flow cytometry/Cell sorting to show a metabolic requirement of dietary protein in sustaining functional CD8 memory.

Sun Jan 01 00:00:00 EST 2012

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.

Nature immunology

Yang CY,Best JA,Knell J,Yang E,Sheridan AD,Jesionek AK,Li HS,Rivera RR,Lind KC,D'Cruz LM,Watowich SS,Murre C,Goldrath AW

25-1271 was used in Flow cytometry/Cell sorting to elucidate the mechanisms of regulation of terminal differentiation of CD8(+) T cells.

Sun Nov 06 00:00:00 EDT 2011

A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells.

The Journal of experimental medicine

Zhao C,Davies JD

25-1271 was used in Flow cytometry/Cell sorting to support a key role for CD4(+) CD44(v.low) cells as peripheral precursors that maintain the integrity of the CD4(+) T cell pool.

Mon Dec 20 00:00:00 EST 2010

Route of adenovirus-based HIV-1 vaccine delivery impacts the phenotype and trafficking of vaccine-elicited CD8+ T lymphocytes.

Journal of virology

Kaufman DR,Bivas-Benita M,Simmons NL,Miller D,Barouch DH

25-1271 was used in Flow cytometry/Cell sorting to indicate that the anatomic microenvironment of antigen expression critically impacts the phenotype and trafficking of antigen-specific CD8(+) T lymphocytes.

Tue Jun 01 00:00:00 EDT 2010

Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization.

Journal of virology

Bivas-Benita M,Bar L,Gillard GO,Kaufman DR,Simmons NL,Hovav AH,Letvin NL

25-1271 was used in Flow cytometry/Cell sorting to evaluate the ability of plasmid DNA to induce antigen-specific immune cell responses after pulmonary administration.

Tue Jun 01 00:00:00 EDT 2010

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.

The Journal of experimental medicine

Chorro L,Sarde A,Li M,Woollard KJ,Chambon P,Malissen B,Kissenpfennig A,Barbaroux JB,Groves R,Geissmann F

25-1271 was used in Flow cytometry/Cell sorting to investigate the mechanisms involved in Langerhans cell development and homeostasis.

Mon Dec 21 00:00:00 EST 2009

Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.

Journal of immunology (Baltimore, Md. : 1950)

Walsh KP,Brady MT,Finlay CM,Boon L,Mills KH

25-1271 was used in Flow cytometry/Cell sorting to provide evidence that parasites can exert bystander immunosuppression of pathogenic T cells that mediate autoimmune diseases.

Sat Aug 01 00:00:00 EDT 2009

LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.

Journal of immunology (Baltimore, Md. : 1950)

Vondenhoff MF,Greuter M,Goverse G,Elewaut D,Dewint P,Ware CF,Hoorweg K,Kraal G,Mebius RE

Fri May 01 00:00:00 EDT 2009

Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination.

Journal of immunology (Baltimore, Md. : 1950)

Kaufman DR,Liu J,Carville A,Mansfield KG,Havenga MJ,Goudsmit J,Barouch DH

25-1271 was used in Flow cytometry/Cell sorting to evaluate mucosal cellular immune responses in mice and rhesus monkeys after systemic immunisation with various replication-incompetent recombinant adenovirus vectors.

Mon Sep 15 00:00:00 EDT 2008

Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis.

Journal of virology

Hovav AH,Cayabyab MJ,Panas MW,Santra S,Greenland J,Geiben R,Haynes BF,Jacobs WR,Letvin NL

25-1271 was used in Flow cytometry/Cell sorting to investigate novel priming immunogens that might be used in heterologous immunization regimens, showing that priming with Mycobacterium smegmatis leads to rapid memory CD8+ T-lymphocyte induction.

Mon Jan 01 00:00:00 EST 2007

Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.

The American journal of pathology

Leithäuser F,Meinhardt-Krajina T,Fink K,Wotschke B,Möller P,Reimann J

Thu Jun 01 00:00:00 EDT 2006

生物信息学

蛋白别名: CD127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R α; IL 7Ra; IL 7Rα; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; IL7 receptor; IL7 receptor subunit alpha; IL7R a; IL7R alpha; IL7R subunit alpha; IL7R α; IL7Rα; interleukin 7 receptor alpha chain; Interleukin-7 receptor subunit alpha; Interleukin7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R

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基因别名: CD127; IL-7Ralpha; Il7r

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UniProt ID: (Mouse) P16872

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Entrez Gene ID: (Mouse) 16197

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功能

cytokine receptor activity transmembrane signal receptor

参与通路