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Streamline formulation and filling with closed, automated design
The CTS Compleo system combines a closed, automated design with intuitive software to maintain aseptic integrity, reduce cell exposure time, and increase consistency in cell therapy formulation and filling. Its modularity and flexible integration options help streamline workflows, reduce risk, and support efficient, high-quality cell therapy manufacturing.
Reduce risks that can impact quality and safety
The CTS Compleo system positively transforms formulation and filling by combining automation, accuracy, and ease-of-use to help ensure consistency and quality in every batch.
Compared to manual methods, the CTS Compleo system helps:
- Reduce risk
- improve quality and manufacturing consistency
- Simplify formulation and fill operations
Advantages of the Compleo system over a manual formulation and fill workflow
| Process impact | Manual workflow | CTS Compleo system |
|---|---|---|
| Helps ensure aseptic integrity through closed system processing including in-process sampling and automated or manual air removal* from cryobags | — | +++ |
| Reduces manual effort and documentation errors, with automated pre-run system checks, volume verification and optional software** to support cGMP lab use | — | +++ |
| Software algorithm automates calculations, reduces manual errors, and optimizes cell usage to help reduce cell waste | — | +++ |
| Software supports scaling to accommodate variable batch sizes without protocol requalification | — | +++ |
| Reduces cryoreagent (active ingredient) exposure† through rapid, automated formulation and fill processing that reduces operator-dependent variability | — | +++ |
* Automated and manual air removal from cryobags without the need to disconnect the output bag, transfer to a safety bio-cabinet, and use a syringe to remove air. 'Air removal’ refers to burping—the controlled release of trapped air, not complete air elimination.
** Optional security, audit, and e-signature (SAE) software helps enable 21 CFR Part 11 compliance.
† As little as 15 min for CTS Compleo system compared to an average of 45 min for manual methods. A lower cryoprotective agent exposure time minimizes unwanted side effects.
Key features of the CTS Compleo automated formulation and fill system
Each part of the CTS Compleo system has been designed to enable users to easily and effectively optimize formulation and filling.*
Instrument
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Single-use kit
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Software
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*Optional configuration coming soon: A cleanroom-compatible tablet and keyboard as an alternative to the laptop for the CTS Compleo system.
** Patent pending
Modular by design for easy integration with a cell processing system of your choice
Discover the easy integration of the CTS Rotea and Compleo systems, where exceptional cell processing meets precise formulation and filling.
- Easy integration—CTS Compleo system works in harmony with the CTS Rotea system to enable efficient formulation and filling coupled with exceptional cell processing
- System agnostic—CTS Compleo system can be implemented with other cell processing platforms to enhance formulation and filling efficiency workflows
| Application | Benefits | |
CTS Rotea System |
Engineered for exceptional cell processing |
|
 CTS Compleo System |
Designed for formulation and filling |
|
CTS Compleo and CTS Rotea Systems side by side. Shown here with the CTS Rotea system (left), the CTS Compleo system (right) is platform agnostic and can be integrated with other cell processing technologies to enhance formulation and filling efficiency across diverse workflows.
Part of a unified, end-to-end cell therapy manufacturing ecosystem
The CTS Compleo system can be used alongside other Thermo Fisher Scientific cell therapy instruments including the CTS DynaCellect Magnetic Separation System for efficient cell isolation, the CTS Rotea System for gentle and consistent cell processing, and the CTS Xenon Electroporation System for reliable cell transfection. Together, these complementary technologies create a cohesive, end-to-end workflow that enhances process efficiency, maintains cell quality, and supports the transition from research to clinical and commercial manufacturing.
The Gibco Cell Therapy Systems (CTS) portfolio of reagents, media, instruments, and viral vector systems is GMP-manufactured, safety-tested, and backed by regulatory documentation to support commercial manufacturing. Designed to help streamline development, minimize risk, and ease quality system burdens, the CTS portfolio enables connected solutions for every stage of your cell therapy process.
Software to enable 21 CFR Part 11 compliance
When you scale up to commercial manufacturing, we recommend upgrading to the CTS Compleo SAE Software to enable 21 CFR part 11 compliance.
Regulatory documentation and support
Choosing a system that supports regulatory requirements is critical for the long-term success of therapeutic development and has significant implications for clinical translation and manufacturability. Investing in the development of a closed, scalable automated system prior to regulatory approval can help reduce risk and potential time lost to manual systems during the progression from process development to commercialization. The Gibco CTS Compleo system supports efficient and effective cell therapy manufacturing by reducing human error and allowing scientists to spend their time on critical thinking steps while the system enables reliable and reproducible results that do not sacrifice the quality of manual processing.
For Research Use or Manufacturing of Cell, Gene, or Tissue-Based Products.